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Publikationen der Abteilung Biochemie

Vollständige und ausgewählte Publikationslisten der Professoren sowie der wissenschaftlichen Mitarbeitenden finden Sie auf dieser Seite.

Publikationen der Abteilung Biochemie

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Imre L, Simándi Z, Horváth A, Fenyőfalvi G, Nánási P, Niaki EF, Hegedüs É, Bacsó Z, Weyemi U, Mauser R, Ausio J, Jeltsch A, Bonner W, Nagy L, Kimura H, Szabó G (2017) Nucleosome stability measured in situ by automated quantitative imaging. Sci Rep. 7(1):12734. PMID: 28986581

Mauser R, Kungulovski G, Keup C, Reinhardt R, Jeltsch A. (2017) Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state. Epigenetics Chromatin. 10(1):45. PMID: 28946896

Lungu C, Pinter S, Broche J, Rathert P, Jeltsch A.(2017)  Modular fluorescence complementation sensors for live cell detection of epigenetic signals at endogenous genomic sites. Nat Commun. 8(1):649. PMID: 28935858
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LABOonline -  Epigenetische Informationen aus lebenden Zellen gewinnen Link

Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y, Defossez PA. (2017) Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation. Mol Cell, 67(4):550-565. PMID: 28803780

Engmann O, Labonté B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh YE, Walker DM, Burek D, Hamilton PJ, Issler O, Neve RL, Turecki G, Hurd Y, Chess A, Shen L, Mansuy I, Jeltsch A, Akbarian S, Nestler EJ (2017) Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2. Biol Psychiatry, in press. PMID: 28577753

Maier JAH, Möhrle R, Jeltsch A (2017) Design of synthetic epigenetic circuits featuring memory effects and reversible switching based on DNA methylation. Nat Commun. 8:15336. PMID: 28537256
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Rusk N (2017) Synthetic biology: Synthetic epigenetic memory. Nat. Methods 14, 764-765. Journal Link
Tuzman KT (2017) Synthetic record. Biocentury Innovations, Translation in Brief, Jul 13. Journal Link

Bashtrykov P, Jeltsch A (2017) Epigenome Editing in the Brain. Adv Exp Med Biol. 978:409-424. PMID: 28523558

Song J, Cano-Rodriquez D, Winkle M, Gjaltema RA, Goubert D, Jurkowski TP, Heijink IH, Rots MG, Hylkema MN (2017) Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 312(3):L334-L347. PMID: 28011616

Weirich S, Kudithipudi S, Jeltsch A (2017) Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex. Mol Oncol. 11:373-387. PMID: 28182322

Kudithipudi S, Schuhmacher MK, Kebede AF, Jeltsch A (2017) The SUV39H1 Protein Lysine Methyltransferase Methylates Chromatin Proteins Involved in Heterochromatin Formation and VDJ Recombination. ACS Chem Biol. 12:958-968. PMID: 28169523

Kusevic D, Kudithipudi S, Iglesias N, Moazed D, Jeltsch A (2017) Clr4 specificity and catalytic activity beyond H3K9 methylation. Biochimie 135:83-88. PMID: 28143796

Stepper P, Kungulovski G, Jurkowska RZ, Chandra T, Krueger F, Reinhardt R, Reik W, Jeltsch A, Jurkowski TP (2017) Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase. Nucleic Acids Res. 45:1703-13. PMID: 27899645

Design of synthetic epigenetic circuits featuring memory effects and reversible
 
Amm I, Kawan M, Wolf DH (2016) Characterization of protein quality control components via dual reporter-containing misfolded cytosolic model substrates. Anal Biochem. 515:14-21. PMID: 27670725

Jurkowska RZ, Jeltsch A (2016) Enzymology of Mammalian DNA Methyltransferases. Adv Exp Med Biol. 945:87-122. PMID: 27826836

Jurkowska RZ, Jeltsch A (2016) Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges. Adv Exp Med Biol. 945:1-17. PMID: 27826832

Kaiser S, Jurkowski TP, Kellner S, Schneider D, Jeltsch A, Helm M (2016) The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA. RNA Biol., in press. PMID: 27819523

Kudithipudi S, Jeltsch A (2016) Approaches and Guidelines for the Identification of Novel Substrates of Protein Lysine Methyltransferases. Cell Chem Biol. 23(9):1049-55. PMID: 27569752

Jeltsch A, Jurkowska RZ (2016) Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm. Nucleic Acids Res. 44(18):8556-8575. PMID: 27521372

Hore TA, von Meyenn F, Ravichandran M, Bachman M, Ficz G, Oxley D, Santos F, Balasubramanian S, Jurkowski TP, Reik W (2016) Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms. Proc Natl Acad Sci U S A. 113(43):12202-12207. PMID: 27729528

Schuhmacher MK, Kudithipudi S, Jeltsch A. (2016) Investigation of H2AX methylation by the SUV39H2 protein lysine methyltransferase. FEBS Lett. 590(12):1713-9. PMID: 27177470

Amm I, Wolf DH. (2016) Molecular mass as a determinant for nuclear San1-dependent targeting of misfolded cytosolic proteins to proteasomal degradation. FEBS Lett. 590(12):1765-75. PMID: 27173001

Jeltsch A, Ehrenhofer-Murray A, Jurkowski T, Lyko F, Reuter G, Ankri S, Nellen W, Schaefer M, Helm M. (2016) Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation. RNA Biol., in press. PMID: 27232191

Weirich S, Kudithipudi S, Jeltsch A. (2016) Specificity of the SUV4-20H1 and SUV4-20H2 protein lysine methyltransferases and methylation of novel substrates. J Mol Biol. 2016 428(11):2344-58. PMID: 27105552

Kungulovski G, Mauser R, Reinhardt R, Jeltsch A. (2016) Application of recombinant TAF3 PHD domain instead of anti-H3K4me3 antibody. Epigenetics Chromatin 22,9:11. PMID: 27006701

Lukashevich OV, Cherepanova NA, Jurkovska RZ, Jeltsch A, Gromova ES. (2016) Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity. BMC Biochem. 17:7. PMID: 27001594

Kusevic D, Kudithipudi S, Jeltsch A. (2016) Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates. J Biol Chem. 291(12):6124-33. PMID: 26797129

Bashtrykov P, Kungulovski G, Jeltsch A (2016) Correction of aberrant imprinting by allele specific epigenome editing. Clin Pharmacol Ther. 99(5):482-4. PMID: 26537177

Kungulovski G, Jeltsch A. (2016) Epigenome Editing: State of the Art, Concepts, and Perspectives. Trends Genet. 32(2):101-113. PMID: 26732754

Hoenicka H, Lehnhardt D, Nunna S, Reinhardt R, Jeltsch A, Briones V, Fladung M (2016) Level of tissue differentiation influences the activation of a heat-inducible flower-specific system for genetic containment in poplar (Populus tremula L.). Plant Cell Rep. 35(2):369-84. PMID: 26521210
 
Kungulovski G, Mauser R, Jeltsch A (2015) Affinity reagents for studying histone modifications & guidelines for their quality control. Epigenomics 7(7):1185-96. PMID: 26541466

Amm I, Norell D, Wolf DH (2015) Absence of the Yeast Hsp31 Chaperones of the DJ-1 Superfamily Perturbs Cytoplasmic Protein Quality Control in Late Growth Phase. PLoS One 10(10):e0140363. PMID: 26466368

Pfirrmann T, Villavicencio-Lorini P, Subudhi AK, Menssen R, Wolf DH, Hollemann T (2015) RMND5 from Xenopus laevis is an E3 ubiquitin-ligase and functions in early embryonic forebrain development. PLoS One 10(3):e0120342. PMID: 25793641

Menssen R, Wolf DH (2015) Ubiquitin-Proteasom-gesteuerte Regulation und Qualitätskontrolle der Zelle. BIOspektrum 21(6): 608-611. Publisher Link

Kungulovski G and Jeltsch A (2015) Quality of histone modification antibodies undermines chromatin biology research. F1000Research 4:1160. Publisher Link

Patalano S, Vlasova A, Wyatt C, Ewels P, Camara F, Ferreira PG, Asher CL, Jurkowski TP, Segonds-Pichon A, Bachman M, González-Navarrete I, Minoche AE, Krueger F, Lowy E, Marcet-Houben M, Rodriguez-Ales JL, Nascimento FS, Balasubramanian S, Gabaldon T, Tarver JE, Andrews S, Himmelbauer H, Hughes WO, Guigó R, Reik W, Sumner S. (2015) Molecular signatures of plastic phenotypes in two eusocial insect species with simple societies. Proc Natl Acad Sci U S A. 112(45):13970-5. PMID: 26483466

Maier JA, Albu RF, Jurkowski TP, Jeltsch A (2015) Investigation of the C-terminal domain of the bacterial DNA-(adenine N6)-methyltransferase CcrM. Biochimie 119:60-7. PMID: 26475175

Kungulovski G, Kycia I, Mauser R, Jeltsch A (2015) Specificity Analysis of Histone Modification-Specific Antibodies or Reading Domains on Histone Peptide Arrays. Methods Mol Biol. 1348:275-84. PMID: 26424280

Weirich S, Kusevic D, Kudithipudi S, Jeltsch A (2015) Investigation of the methylation of Numb by the SET8 protein lysine methyltransferase. Sci Rep. 5:13813. PMID: 26391684

Delatte B, Jeschke J, Defrance M, Bachman M, Creppe C, Calonne E, Bizet M, Deplus R, Marroquí L, Libin M, Ravichandran M, Mascart F, Eizirik DL, Murrell A, Jurkowski TP, Fuks F. (2015) Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress. Sci Rep. 5:12714. PMID: 26239807

A Jeltsch, W Wende, P Friedhoff, BL Stoddard (2015) Editorial: Alfred Pingoud (1945–2015). Nucleic Acids Research 43 (16), 7661-7663. Publisher Link

Shanmugam R, Fierer J, Kaiser S, Helm M, Jurkowski TP, Jeltsch A (2015) Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences. Cell Discovery 1:15010. Publisher Link

Kungulovski G, Nunna S, Thomas M, Zanger UM, Reinhardt R, Jeltsch A (2015) Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained. Epigenetics Chromatin 8:12. PMID: 25901185

Subinya M, Steudle AK, Jurkowski TP, Stubenrauch C. (2015) Conformation and activity of lipase B from Candida antarctica in bicontinuous microemulsions. Colloids Surf B Biointerfaces. 131:108-14. PMID: 25973762

Weirich S, Kudithipudi S, Kycia I, Jeltsch A. (2015) Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme. Clin. Epigenetics 7(1), 36. PMID: 25829971

Voelcker-Rehage C, Jeltsch A, Godde B, Becker S, Staudinger UM (2015) COMT gene polymorphisms, cognitive performance, and physical fitness in older adults. Psychology of Sport and Exercise, 20, 230-28. Publisher Link

Lungu C, Muegge K, Jeltsch A, Jurkowska RZ (2015) An ATPase-deficient variant of the SNF2 family member HELLS shows altered dynamics at pericentromeric heterochromatin. J. Mol. Biol. 427(10), 1903-15. PMID: 25823553

Elhardt W, Shanmugam R, Jurkowski TP, Jeltsch A. (2015) Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties. Biochimie 112, 66-72. PMID: 25747896

Pfirrmann T, Villavicencio-Lorini P, Subudhi AK, Menssen R, Wolf DH, Hollemann T. (2015) RMND5 from Xenopus laevis Is an E3 Ubiquitin-Ligase and Functions in Early Embryonic Forebrain Development. PLOS One 10(3), e0120342. PMID: 25793641

Jurkowski TP, Ravichandran M, Stepper P (2015) Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity. Clin Epigenetics 7, 18. PMID: 25741388

Maier JAH, Ragozin S, Jeltsch A (2015) Identification, cloning and heterologous expression of active [NiFe]-hydrogenase 2 from Citrobacter sp. SG in Escherichia coli. J. Biotech. 199, 1-8. PMID: 25678135

Bashtrykov P, & Jeltsch A (2015) DNMT1-associated DNA methylation changes in cancer. Cell Cycle 14, 5. PMID: 25483051

Scazzari M, Amm I, Wolf DH (2015) Quality control of a cytoplasmic protein complex: Chaperone motors and the ubiquitin-proteasome system govern the fate of orphan fatty acid synthase subunit Fas2 of yeast. J. Biol. Chem. 290, 4677-87. PMID: 25564609

Schuhmacher MK, Kudithipudi S, Kusevic D, Weirich S, & Jeltsch A (2015) Activity and specificity of the human SUV39H2 protein lysine methyltransferase. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1849(1):55-63. PMID: 25459750 
Kudithipudi S, Kusevic D, Weirich S, & Jeltsch A (2014) Specificity Analysis of Protein Lysine Methyltransferases Using SPOT Peptide Arrays. Journal of Visualized Experiments (93):e52203. PMID: 25489813
Link to the JoVE Video @ Uni Stuttgart

Kungulovski G, Kycia I, Tamas R, Jurkowska RZ, Kudithipudi S, Henry C, Reinhardt R, Labhart P, & Jeltsch A. (2014) Application of histone modification-specific interaction domains as an alternative to antibodies. Genome Res. 24 (11), 1842-1853. PMID: 25301795

Emperle M, Rajavelu A, Reinhardt R, Jurkowska RZ, & Jeltsch A (2014) Cooperative DNA binding and protein/DNA fiber formation increases the activity of the Dnmt3a DNA methyltransferase. J. Biol. Chem. 289 (43), 29602-29613. PMID: 25147181

Kudithipudi S, & Jeltsch A (2014) Role of somatic cancer mutations in human protein lysine methyltransferases. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1846(2):366-379 PMID: 25123655

Deplus R, Blanchon L, Rajavelu A, Boukaba A, Defrance M, Luciani J, Rothé F, Dedeurwaerder S, Denis H, Brinkman AB, Simmer F, Müller F, Bertin B, Berdasco M, Putmans P, Calonne E, Litchfield DW, de Launoit Y, Jurkowski TP, Stunnenberg HG, Bock C, Sotiriou C, Fraga MF, Esteller M, Jeltsch A & Fuks F. (2014) Regulation of DNA Methylation Patterns by CK2-Mediated Phosphorylation of Dnmt3a. Cell Reports 8(3):743-53 PMID: 25066127

Jeltsch A & Jurkowska RZ (2014) New concepts in DNA methylation. Trends Biochem Sci. 39, 310-18. PMID: 24947342

Guitot K, Scarabelli S, Drujon T, Bolbach G, Amoura M, Burlina F, Jeltsch A, Sagan S, Guianvarc'h D (2014) Label-free measurement of histone lysine methyltransferases activity by MALDI-TOF mass spectrometry. Analytical Biochem. 456:25-31 PMID: 24747023

Shanmugam R, Aklujkar M, Schäfer M, Reinhardt R, Nickel O, Reuter G, Lovley DR, Ehrenhofer-Murray A, Nellen W, Ankri S, Helm M, Jurkowski TP, & Jeltsch A.(2014) The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu. Nucl. Acids Res. 42(10):6487-96 PMID: 24711368

Rilova E, Erdmann A, Gros C, Masson V, Aussagues Y, Poughon-Cassabois V, Rajavelu A, Jeltsch A, Menon Y, Novosad N, Gregoire JM, Vispé S, Schambel P, Ausseil F, Sautel F, Arimondo PB, Cantagrel F.(2014) Design, Synthesis and Biological Evaluation of 4-Amino-N-(4-aminophenyl)benzamide Analogues of Quinoline-Based SGI-1027 as Inhibitors of DNA Methylation. ChemMedChem 9(3):590-601 PMID: 24678024

Bashtrykov P, Rajavelu A, Hackner B, Ragozin S, Carell T & Jeltsch A.(2014) Targeted Mutagenesis Results in an Activation of DNA Methyltransferase 1 and Confirms an Autoinhibitory Role of its RFTS Domain. ChemBioChem 15(5):743-8. PMID: 24532244

Nunna S, Reinhardt R, Ragozin S, Jeltsch A (2014) Targeted Methylation of the Epithelial Cell Adhesion Molecule (EpCAM) Promoter to Silence Its Expression in Ovarian Cancer Cells. PLoS One 9(1):e87703. PMID: 24489952

Kudithipudi S, Lungu C, Rathert P, Happel N & Jeltsch A (2014) Substrate Specificity Analysis and Novel Substrates of the Protein Lysine Methyltransferase NSD1. Chemistry & Biology 21(2):226-37. PMID: 24412544

Amm I, Sommer T, & Wolf DH (2014) Protein quality control and elimination of protein waste: The role of the ubiquitin-proteasome system. Biochim Biophys Acta. 1843(1):182-96. PMID: 23850760

Asgatay S, Champion C, Marloie G, Drujon T, Senamaud-Beaufort C, Ceccaldi A, Erdmann A, Rajavelu A, Schambel P, Jeltsch A, Lequin O, Karoyan P, Arimondo PB & Guianvarc'h D. (2014) Synthesis and Evaluation of Analogues of N-Phthaloyl-L-tryptophan (RG108) as Inhibitors of DNA Methyltransferase 1. J. Med. Chem. 57(2):421-34. PMID: 24328113

Bashtrykov P, Jankevicius G, Jurkowska RZ, Ragozin S, & Jeltsch A. (2014) The Uhrf1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase Dnmt1 by an allosteric mechanism. J. Biol. Chem. 289(7), 4106-15. PMID: 24368767
 
Jurkowska,ZR & Jeltsch A (2013) Genomic Imprinting—The Struggle of the Genders at the Molecular Level. Angewandte Chemie 52, 13524-36. PMID: 24346936

Stolz A, Besser S, Hottmann H & Wolf DH(2013) Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation. PNAS 110, 15271-6. PMID: 23988329

Kycia I, Kudithipudi S, Tamas R, Kungulovski G, Dhayalan A, Jeltsch A (2013)The Tudor Domain of the PHD Finger Protein 1 Is a Dual Reader of Lysine Trimethylation at Lysine 36 of Histone H3 and Lysine 27 of Histone Variant H3t. J. Mol. Biol. 426(8):1651-60. PMID: 23954330

Müller S, Windhof IM, Maximov V, Jurkowski T, Jeltsch A, Förstner KU, Sharma CM, Gräf R, & Nellen W. (2013) Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA). Nucl. Acids Res. 41, 8615-27. PMID: 23877245

Kudithipudi, S., Kusevic, D., Jeltsch A. (2013) Non-radioactive Protein Lysine Methyltransferase Microplate Assay Based on Reading Domains. ChemMedChem 9(3):554-9. PMID: 23671032

Jeltsch A. & Jurkowska, R.Z. (2013) Multimerization of the Dnmt3a DNA Methyltransferase and its Functional Implications. Prog Mol Biol Transl Sci. 117, 445-64. PMID: 23663978

Jeltsch A. (2013) Oxygen, epigenetic signaling and the evolution of early life. Trends in Biochemical Sciences, 38(4):172-6. PMID: 23454078

Ceccaldi A, Rajavelu A, Ragozin S, Sénamaud-Beaufort C, Bashtrykov P, Testa N, Dali-Ali H, Maulay-Bailly C, Amand S, Guianvarc'h D, Jeltsch A, Arimondo PB. (2013) Identification of Novel Inhibitors of DNA Methylation by Screening of a Chemical Library. ACS Chem Biol. 8(3):543-8. PMID: 23294304

Siddique AN, Nunna S, Rajavelu A, Zhang Y, Jurkowska RZ, Reinhardt R, Rots MG, Ragozin S, Jurkowski TP, Jeltsch A. (2013) Targeted Methylation and Gene Silencing of VEGF-A in Human Cells by Using a Designed Dnmt3a-Dnmt3L Single-Chain Fusion Protein with Increased DNA Methylation Activity. J Mol Biol. 2013;425(3):479-91. PMID: 23220192
  
Becker M, Müller S, Nellen W, Jurkowski TP, Jeltsch A, Ehrenhofer-Murray AE. Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. Nucleic Acids Res. 2012 Dec 1;40(22):11648-58. PMID: 23074192

Fahy J, Jeltsch A, Arimondo PB. DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies. Expert Opin Ther Pat. 2012 Dec;22(12):1427-42. PMID: 23033952

Kutscher D, Pingoud A, Jeltsch A, Meiss G. Identification of ICAD-derived peptides capable of inhibiting caspase-activated DNase. FEBS J. 2012 Aug;279(16):2917-28. PMID: 22727028

Menssen R, Schweiggert J, Schreiner J, Kusevic D, Reuther J, Braun B, Wolf DH. Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. J Biol Chem. 2012 Jul 20;287(30):25602-14. doi: 10.1074/jbc.M112.363762. Epub 2012 May 29. PMID:22645139

Bashtrykov P, Ragozin S, Jeltsch A. Mechanistic details of the DNA recognition by the Dnmt1 DNA methyltransferase. FEBS Lett. 2012 Jun 21;586(13):1821-3. PMID: 22641038

Bashtrykov P, Jankevicius G, Smarandache A, Jurkowska RZ, Ragozin S, Jeltsch A. Specificity of Dnmt1 for methylation of hemimethylated CpG sites resides in its catalytic domain. Chem Biol. 2012;19(5):572-8. PMID: 22633409

Albu RF, Zacharias M, Jurkowski TP, Jeltsch A. DNA interaction of the CcrM DNA methyltransferase: a mutational and modeling study. Chembiochem. 2012 Jun 18;13(9):1304-11. PMID: 22639453

Jurkowski TP, Shanmugam R, Helm M, Jeltsch A.Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase. Biochemistry. 2012 Jun 5;51(22):4438-44. PMID: 22591353

Kudithipudi S, Dhayalan A, Kebede AF, Jeltsch A.The SET8 H4K20 protein lysine methyltransferase has a long recognition sequence covering seven amino acid residues. Biochimie. 2012;94(11):2212-8. PMID: 22583696

Stolz A, Wolf DH. Use of CPY and its derivatives to study protein quality control in various cell compartments. Methods Mol Biol. 2012;832:489-504. PMID: 22350908

Florea M, Kudithipudi S, Rei A, González-Álvarez MJ, Jeltsch A, Nau WM. A fluorescence-based supramolecular tandem assay for monitoring lysine methyltransferase activity in homogeneous solution. Chemistry. 2012;18(12):3521-8. PMID: 22367964

Halby L, Champion C, Sénamaud-Beaufort C, Ajjan S, Drujon T, Rajavelu A, Ceccaldi A, Jurkowska R, Lequin O, Nelson WG, Guy A, Jeltsch A, Guianvarc'h D, Ferroud C, Arimondo PB. Rapid synthesis of new DNMT inhibitors derivatives of procainamide. Chembiochem. 2012;13(1):157-65. PMID: 22170584
 
 
 

Jurkowski TP, Jeltsch A. On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2. PLoS One. 2011;6(11):e28104. PMID: 22140515

Jeltsch A. Epigenetics Europe conference. Munich, Germany, 8-9 September 2011. Epigenomics. 2011;3(6):693-5. PMID: 22126289

Jurkowski TP, Jeltsch A. Burning off DNA methylation: new evidence for oxygen-dependent DNA demethylation. Chembiochem. 2011 Nov 25;12(17):2543-5. PMID: 21998074

Bonnist EY, Liebert K, Dryden DT, Jeltsch A, Jones AC. Using the fluorescence decay of 2-aminopurine to investigate conformational change in the recognition sequence of the EcoRV DNA-(adenine-N6)-methyltransferase on enzyme binding. Biophys Chem. 2012;160(1):28-34. PMID: 21962489

Rajavelu A, Jurkowska RZ, Fritz J, Jeltsch A. Function and disruption of DNA methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation. Nucleic Acids Res. 2012;40(2):569-80. PMID: 21926161

Martinez Benitez E, Stolz A, Becher A, Wolf DH. Mnl2, a novel component of the ER associated protein degradation pathway. Biochem Biophys Res Commun. 2011;414(3):528-32. PMID: 21971548

Albu RF, Jurkowski TP, Jeltsch A. The Caulobacter crescentus DNA-(adenine-N6)-methyltransferase CcrM methylates DNA in a distributive manner.Nucleic Acids Res. 2012;40(4):1708-16. PMID: 21926159

Wolf DH, Stolz A. The Cdc48 machine in endoplasmic reticulum associated protein degradation. Biochim Biophys Acta. 2012;1823(1):117-24. PMID: 21945179

Jurkowska RZ, Ceccaldi A, Zhang Y, Arimondo PB, Jeltsch A. DNA methyltransferase assays. Methods Mol Biol. 2011;791:157-77. PMID: 21913079

Bock I, Kudithipudi S, Tamas R, Kungulovski G, Dhayalan A, Jeltsch A. Application of Celluspots peptide arrays for the analysis of the binding specificity of epigenetic reading domains to modified histone tails.BMC Biochem. 2011;12:48. PMID: 21884582

Benitez EM, Stolz A, Wolf DH. Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD. FEBS Lett. 2011;585(19):3015-9. PMID: 21871892

Wolf DH. The ubiquitin clan: A protein family essential for life. FEBS Lett. 2011;585(18):2769-71. PMID: 21867706

Ceccaldi A, Rajavelu A, Champion C, Rampon C, Jurkowska R, Jankevicius G, Sénamaud-Beaufort C, Ponger L, Gagey N, Ali HD, Tost J, Vriz S, Ros S, Dauzonne D, Jeltsch A, Guianvarc'h D, Arimondo PB.C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development. Chembiochem. 2011;12(9):1337-45. PMID: 21633996

Li BZ, Huang Z, Cui QY, Song XH, Du L, Jeltsch A, Chen P, Li G, Li E, Xu GL. Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase. Cell Res. 2011;21(8):1172-81. PMID: 21606950

Jurkowska RZ, Rajavelu A, Anspach N, Urbanke C, Jankevicius G, Ragozin S, Nellen W, Jeltsch A. Oligomerization and binding of the Dnmt3a DNA methyltransferase to parallel DNA molecules: heterochromatic localization and role of Dnmt3L. J Biol Chem. 2011;286(27):24200-7. PMID: 21566127

Stolz A, Hilt W, Buchberger A, Wolf DH. Cdc48: a power machine in protein degradation. Trends Biochem Sci. 2011;36(10):515-23. PMID: 21741246

Rajavelu A, Tulyasheva Z, Jaiswal R, Jeltsch A, Kuhnert N. The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols. BMC Biochem. 2011;12:16. PMID: 21510884

Siddique AN, Jurkowska RZ, Jurkowski TP, Jeltsch A. Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue. FEBS J. 2011;278(12):2055-63. PMID: 21481189

Dhayalan A, Tamas R, Bock I, Tattermusch A, Dimitrova E, Kudithipudi S, Ragozin S, Jeltsch A. The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9.Hum Mol Genet. 2011;20(11):2195-203. PMID: 21421568

Jurkowska RZ, Siddique AN, Jurkowski TP, Jeltsch A. Approaches to enzyme and substrate design of the murine Dnmt3a DNA methyltransferase. Chembiochem. 2011;12(10):1589-94. PMID: 21400651

Dhayalan A, Kudithipudi S, Rathert P, Jeltsch A. Specificity analysis-based identification of new methylation targets of the SET7/9 protein lysine methyltransferase. Chem Biol. 2011;18(1):111-20. PMID: 21276944

Jurkowska RZ, Jurkowski TP, Jeltsch A. Structure and function of mammalian DNA methyltransferases. Chembiochem. 2011;12(2):206-22. Review. PMID: 21243710

Jeltsch A, Fischle W. Molecular epigenetics: connecting human biology and disease with little marks. Chembiochem. 2011;12(2):183-4. PMID: 21243707

Bock I, Dhayalan A, Kudithipudi S, Brandt O, Rathert P, Jeltsch A. Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays. Epigenetics. 2011;6(2):256-63. PMID: 20962581

Eisele F, Schäfer A, Wolf DH. Ubiquitylation in the ERAD Pathway. Subcell Biochem. 2010;54:136-48. PMID: 21222279.

Stolz A, Schweizer RS, Schäfer A, Wolf DH. Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD. Traffic. 2010;11(10):1363-9. PMID: 20579315.

Champion C, Guianvarc'h D, Sénamaud-Beaufort C, Jurkowska RZ, Jeltsch A, Ponger L, Arimondo PB, Guieysse-Peugeot AL. Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine. PLoS One. 2010;5(8):e12388. PMID: 20808780.

Jurkowska RZ, Jeltsch A. Silencing of gene expression by targeted DNA methylation: concepts and approaches. Methods Mol Biol. 2010;649:149-61. PMID: 20680833.

Dhayalan A, Rajavelu A, Rathert P, Tamas R, Jurkowska RZ, Ragozin S, Jeltsch A. The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. J Biol Chem. 2010;285(34):26114-20. PMID: 20547484

Jeltsch A. Molecular biology. Phylogeny of methylomes. Science. 2010;328(5980):837-8. PMID: 20466912

Rohde C, Zhang Y, Reinhardt R, Jeltsch A. BISMA-fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences. BMC Bioinformatics. 2010;11:230. PMID: 20459626

Barbin L, Eisele F, Santt O, Wolf DH. The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase. Biochem Biophys Res Commun. 2010;394(2):335-41. PMID: 20206597.

Zhang Y, Jurkowska R, Soeroes S, Rajavelu A, Dhayalan A, Bock I, Rathert P, Brandt O, Reinhardt R, Fischle W, Jeltsch A. Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Res. 2010;38(13):4246-53. PMID: 20223770

Juretschke J, Menssen R, Sickmann A, Wolf DH. The Hsp70 chaperone Ssa1 is essential for catabolite induced degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase. Biochem Biophys Res Commun. 2010;397(3):447-52. PMID: 20513352

Jurkoska RZ, Jeltsch A. The Chemical Biology of Nucleic Acids In: Mayer G, editor. Chichester, UK: John Wiley & Sons, Ltd.; 2010. DNA Methylation. pp. 307-322.

Stolz A, Wolf DH. Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell. Biochim Biophys Acta. 2010;1803(6):694-705. Review. PMID: 20219571

Zhang Y, Jeltsch A. The Application of Next Generation Sequencing in DNA Methylation Analysis. Genes. 2010; 1(1):85-101.

Zhang Y, Rohde C, Reinhardt R, Voelcker-Rehage C, Jeltsch A. Non-imprinted allele-specific DNA methylation on human autosomes. Genome Biol. 2009;10(12):R138. PMID: 19958531

Rohde C, Zhang Y, Stamerjohanns H, Hecher K, Reinhardt R, Jeltsch A. New clustering module in BDPC bisulfite sequencing data presentation and compilation web application for DNA methylation analyses. Biotechniques. 2009;47(3):781-3. PMID: 19852764

Chahar S, Elsawy H, Ragozin S, Jeltsch A. Changing the DNA recognition specificity of the EcoDam DNA-(adenine-N6)-methyltransferase by directed evolution. J Mol Biol. 2010;395(1):79-88. PMID: 19766657

Dhayalan A, Dimitrova E, Rathert P, Jeltsch A.A continuous protein methyltransferase (G9a) assay for enzyme activity measurement and inhibitor screening. J Biomol Screen. 2009;14(9):1129-33. PMID: 19734436

Elsawy H, Podobinschi S, Chahar S, Jeltsch A. Transition from EcoDam to T4Dam DNA recognition mechanism without loss of activity and specificity. Chembiochem. 2009;10(15):2488-93. PMID: 19725089

Schäfer A, Wolf DH. Sec61p is part of the endoplasmic reticulum-associated degradation machinery. EMBO J. 2009;28(19):2874-84. PMID: 19696741

Pingoud V, Wende W, Friedhoff P, Reuter M, Alves J, Jeltsch A, Mones L, Fuxreiter M, Pingoud A. On the divalent metal ion dependence of DNA cleavage by restriction endonucleases of the EcoRI family. J Mol Biol. 2009;393(1):140-60. PMID: 19682999

Gao T, Collins RE, Horton JR, Zhang X, Zhang R, Dhayalan A, Tamas R, Jeltsch A, Cheng X. The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding. Proteins. 2009;76(3):772-7. PMID: 19434754

Rathert P, Dhayalan A, Ma H, Jeltsch A. Specificity of protein lysine methyltransferases and methods for detection of lysine methylation of non-histone proteins. Mol Biosyst. 2008;4(12):1186-90. Review. PMID: 19396382

Alberts SM, Sonntag C, Schäfer A, Wolf DH. Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum. J Biol Chem. 2009;284(24):16082-9. PMID: 19359248

Zhang Y, Rohde C, Tierling S, Jurkowski TP, Bock C, Santacruz D, Ragozin S, Reinhardt R, Groth M, Walter J, Jeltsch A. DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution. PLoS Genet. 2009;5(3):e1000438. PMID: 19325872

Maltseva DV, Baykov AA, Jeltsch A, Gromova ES.Impact of 7,8-dihydro-8-oxoguanine on methylation of the CpG site by Dnmt3a.Biochemistry. 2009;48(6):1361-8. PMID: 19161295

Jurkowski TP, Jeltsch A. Mechanism and Evolution of DNA Recognition by DNA-(adenine N6)-Methyltransferases from the EcoDam Family. In: Grosjean H, editor. DNA and RNA Modification Enzymes: Comparative Structure, Mechanism, Functions, Cellular Interactions and Evolution Austin (Texas): Landes Bioscience; 2009.

Zhang Y, Rohde C, Tierling S, Stamerjohanns H, Reinhardt R, Walter J, Jeltsch A.DNA methylation analysis by bisulfite conversion, cloning, and sequencing of individual clones.Methods Mol Biol. 2009;507:177-87. PMID: 18987815

Eisele F, Wolf DH. Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1. FEBS Lett. 2008;582(30):4143-6. PMID: 19041308

Jurkowska RZ, Anspach N, Urbanke C, Jia D, Reinhardt R, Nellen W, Cheng X, Jeltsch A. Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Res. 2008;36(21):6656-63. PMID: 18945701

Jeltsch A. Reading and writing DNA methylation. Nat Struct Mol Biol. 2008;15(10):1003-4. PMID: 18836494

Jeltsch A, Rathert P. Putting the pieces together: histone H2B ubiquitylation directly stimulates histone H3K79 methylation. Chembiochem. 2008;9(14):2193-5. PMID: 18712750

Jurkowski TP, Meusburger M, Phalke S, Helm M, Nellen W, Reuter G, Jeltsch A. Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. RNA. 2008;14(8):1663-70. PMID: 18567810

Kohlmann S, Schäfer A, Wolf DH. Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation. J Biol Chem. 2008;283(24):16374-83. PMID: 18436532

Rathert P, Dhayalan A, Murakami M, Zhang X, Tamas R, Jurkowska R, Komatsu Y, Shinkai Y, Cheng X, Jeltsch A.Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol. 2008;4(6):344-6. PMID: 18438403

van der Gun BT, Wasserkort R, Monami A, Jeltsch A, Raskó T, Slaska-Kiss K, Cortese R, Rots MG, de Leij LF, Ruiters MH, Kiss A, Weinhold E, McLaughlin PM. Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation. Int J Cancer. 2008;123(2):484-9. PMID: 18398839

Santt O, Pfirrmann T, Braun B, Juretschke J, Kimmig P, Scheel H, Hofmann K, Thumm M, Wolf DH. The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism. Mol Biol Cell. 2008;19(8):3323-33. PMID: 18508925

Métivier R, Gallais R, Tiffoche C, Le Péron C, Jurkowska RZ, Carmouche RP, Ibberson D, Barath P, Demay F, Reid G, Benes V, Jeltsch A, Gannon F, Salbert G. Cyclical DNA methylation of a transcriptionally active promoter. Nature. 2008;452(7183):45-50. PMID: 18322525

Rohde C, Zhang Y, Jurkowski TP, Stamerjohanns H, Reinhardt R, Jeltsch A. Bisulfite sequencing Data Presentation and Compilation (BDPC) web server--a useful tool for DNA methylation analysis. Nucleic Acids Res. 2008;36(5):e34. PMID: 18296484

Liebert K, Jeltsch A. Detection and quantitation of the activity of DNA methyltransferases using a biotin/avidin microplate assay. Methods Mol Biol. 2008;418:149-56. PMID: 18287657

Rathert P, Zhang X, Freund C, Cheng X, Jeltsch A. Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays. Chem Biol. 2008;15(1):5-11. PMID: 18215768

Dhayalan A, Jurkowski TP, Laser H, Reinhardt R, Jia D, Cheng X, Jeltsch A. Mapping of protein-protein interaction sites by the 'absence of interference' approach. J Mol Biol. 2008;376(4):1091-9. PMID: 18191145

Raasi S, Wolf DH. Ubiquitin receptors and ERAD: a network of pathways to the proteasome. Semin Cell Dev Biol. 2007 Dec;18(6):780-91. Review. PMID: 17942349

Rathert P, Cheng X, Jeltsch A. Continuous enzymatic assay for histone lysine methyltransferases. Biotechniques. 2007 Nov;43(5):6026. PMID: 18072589

Jurkowski TP, Anspach N, Kulishova L, Nellen W, Jeltsch A. The M.EcoRV DNA-(adenine N6)-methyltransferase uses DNA bending for recognition of an expanded EcoDam recognition site. J Biol Chem. 2007;282(51):36942-52. PMID: 17977824

Goyal R, Rathert P, Laser H, Gowher H, Jeltsch A. Phosphorylation of serine-515 activates the Mammalian maintenance methyltransferase Dnmt1. Epigenetics. 2007;2(3):155-60. PMID: 17965600

Jia D, Jurkowska RZ, Zhang X, Jeltsch A, Cheng X. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature. 2007;449(7159):248-51. PMID: 17713477

Gallais R, Demay F, Barath P, Finot L, Jurkowska R, Le Guével R, Gay F, Jeltsch A, Métivier R, Salbert G. Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation. Mol Endocrinol. 2007;21(9):2085-98. PMID: 17579209

Liebert K, Horton JR, Chahar S, Orwick M, Cheng X, Jeltsch A. Two alternative conformations of S-adenosyl-L-homocysteine bound to Escherichia coli DNA adenine methyltransferase and the implication of conformational changes in regulating the catalytic cycle. J Biol Chem. 2007;282(31):22848-55. PMID: 17545164

Jeltsch A, Jurkowska RZ, Jurkowski TP, Liebert K, Rathert P, Schlickenrieder M. Application of DNA methyltransferases in targeted DNA methylation. Appl Microbiol Biotechnol. 2007;75(6):1233-40. Review. PMID: 17431611

Rathert P, Raskó T, Roth M, Slaska-Kiss K, Pingoud A, Kiss A, Jeltsch A. Reversible inactivation of the CG specific SssI DNA (cytosine-C5)-methyltransferase with a photocleavable protecting group. Chembiochem. 2007;8(2):202-7. PMID: 17195251

Park SH, Bolender N, Eisele F, Kostova Z, Takeuchi J, Coffino P, Wolf DH. The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. Mol Biol Cell. 2007;18(1):153-65. PMID: 17065559

Li F, Papworth M, Minczuk M, Rohde C, Zhang Y, Ragozin S, Jeltsch A. Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. Nucleic Acids Res. 2007;35(1):100-12. PMID: 17151075

Kontakt

Dieses Bild zeigt Jeltsch
Prof. Dr.

Albert Jeltsch

Abteilungsleiter Biochemie

 

Abteilung für Biochemie

Allmandring 31, D-70569 Stuttgart