Highlights
Flanking sequence preferences of TET enzymes
Adam et al. (2022) Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns. Communications Biology, 5:92.
Structure of DNMT1 explains base flipping mechanisms
Adam et al. (2020) DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation. Nat Commun. 11:3723.
Specificity of SETD2
Schuhmacher et al. (2020) Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate. Communications Biology 3, 511.
Structure of DNMT3B explains ICF methylation defects.
Gao et al. (2020) Comprehensive Structure-Function Characterization of DNMT3B and DNMT3A Reveals Distinctive De Novo DNA Methylation Mechanisms. Nat Commun. 11:3355.
Engineering of Effector Domains for Targeted DNA Methylation with Reduced Off-Target Effects
Hofacker, Broche, Laistner, Adam, Bashtrykov & Jeltsch (2020) Int J Mol Sci. 21(2):E502
Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns
Emperle, Adam, Kunert, Dukatz, Baude, Plass, Rathert, Bashtrykov & Jeltsch (2019) Nucleic Acids Res. 47(21):11355-11367
The SETDB1 triple Tudor domain binds H3 K9me/K14ac
Jurkowska, Qin, Kungulovski, Tempel, Liu, Bashtrykov, Stiefelmaier, Jurkowski, Kudithipudi, Weirich, Tamas, Wu, Dombrovski, Loppnau, Reinhardt, Min & Jeltsch (2017) Nat Commun. 8(1):2057
Lungu, Pinter, Broche, Rathert & Jeltsch (2017) Nature Communications 8:649
Modular fluorescence complementation sensors for live cell detection of epigenetic signals at endogenous genomic sites.
Maier, Möhrle & Jeltsch (2017) Nature Communcations 8, 15336
Design of synthetic epigenetic circuits featuring memory effects and reversible switching based on DNA methylation.
Kudithipudi & Jeltsch (2016) Cell Chem. Biol. 23, 1049-55
Approaches and Guidelines for the Identification of Novel Substrates of Protein Lysine Methyltransferases.
Kungulovski & Jeltsch (2016) Trends in Genetics 32, 101-113
Epigenome Editing: State of the Art, Concepts, and Perspectives.
Kungulovski et al. (2014) Genome Research 24, 1842-53
Application of histone modification-specific interaction domains as an alternative to antibodies. Genome Research 24(11): 1842-53.
Publikationen der Abteilung Biochemie
Chandrasekaran TC, Choudalakis M, Bröhm A, Weirich S, Kouroukli AG, Ammerpohl O, Rathert P, Bashtrykov P, & Jeltsch A. (2024) SETDB1 activity is globally directed by H3K14 acetylation via its Triple Tudor Domain. Nucl. Acids Res., in press. Publisher-Link
Knodel F, Eirich J, Pinter S, Eisler SA, Finkemeier I, & Rathert P. (2024) The kinase NEK6 positively regulates LSD1 activity and accumulation in local chromatin sub-compartments. Communications Biology 7:1483. Publisher Link
Rajaram N, Benzler K, Bashtrykov P, & Jeltsch A. (2024) Allele-specific DNA demethylation editing leads to stable upregulation of allele-specific gene expression. iScience 27(10):11107. Publisher Link
Weirich S, Kusevic D, Schnee P, Reiter J, Pleiss J & Jeltsch A. (2024) Discovery of new NSD2 non-histone substrates and design of a super-substrate. Communications Biology 7:707. Publisher Link
Dossmann L, Emperle M, Dukatz M, de Mendoza A, Bashtrykov P, Jeltsch A (2024) Specific DNMT3C flanking sequence preferences facilitate methylation of young murine retrotransposons. Communications Biology 7:582. Publisher Link
Yamaguchi K, Chen X, Rodger B, Miura F, Bashtrykov P, Bonhomme F, Salinas-Luypaert C, Haxholli D, Gutekunst N, Ozdemir Aygenli B, Ferry L, Kirsh O, Laisne M, Scelfo A, Ugur E, Arimondo PB, Leonhardt H, Kanemaki MT, Bartke T, Fachinetti D, Jeltsch A, Ito T, Defossez P-A. (2024) Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells. Nature Communications, 15(1):2960. PubMed Link
Choudalakis M, Bashtrykov P*, Jeltsch A* (2024) RepEnTools: An automated repeat enrichment analysis package for ChIP-seq data reveals hUHRF1 Tandem-Tudor domain enrichment in young repeats. Mobile DNA, 15(1):6. PubMed Link
Köhler AR, Haußer J, Harsch A, Bernhardt S, Häußermann L, Brenner L-M, Lungu C, Olayioye MA, Bashtrykov P, Jeltsch A. (2024) Modular dual-color BiAD sensors for locus-specific high sensitivity readout of epigenome modifications in single cells. Cell Reports Methods, 100739. PubMed Link
Schnee P, Pleiss J, Jeltsch A. (2024) Approaching the catalytic mechanism of protein lysine methyltransferases by biochemical and simulation techniques. Critical Reviews in Biochemistry & Molecular Biology, 7:1-49. PubMed Link
Brenner LM, Meyer F, Yang H, Köhler AR, Bashtrykov P, Guo M, Jeltsch A, Lungu C, Olayioye MA. (2024) Repeat DNA methylation is modulated by adherens junction signaling. Comm. Biology, 7(1):286. PubMed Link
Weirich S, Ulu GT, Chandrasekaran TC, Kehl J, Schmid J, Dorscht F, Kublanovsky M, Levy D & Jeltsch A. (2024) Distinct specificities of the HEMK2 protein methyltransferase in methylation of glutamine and lysine residues. Protein Science 33(2):e4897. Publisher Link
Albrecht C, Rajaram N, Broche J, Bashtrykov P, Jeltsch A. (2024) Locus-specific and stable DNA demethylation at the H19/IGF2 ICR1 by epigenome editing using a dCas9-SunTag system and the catalytic domain of TET1. Genes 15(1):80. Publisher Link
Jeltsch A*, Choudalakis M, Dukatz M, Kunert S. (2024) ADD domains—A regulatory hub in chromatin biology and disease. Chromatin Readers in Health and Disease, page 3-11, Volume 35 in Translational Epigenetics, Academic Press, DOI 10.1016/B978-0-12-823376-4.09993-6. Publisher Link
Rots MG, Jeltsch A. Development of Locus-Directed Editing of the Epigenome from Basic Mechanistic Engineering to First Clinical Applications. Methods Mol. Biol. 2841, 3-20 (2024) PubMed Link
Rajaram N, Bashtrykov P, Jeltsch A. Protocol for Allele-Specific Epigenome Editing Using CRISPR/dCas9. Methods Mol. Biol. 2841, 179-192 (2024) PubMed Link
Albrecht C, Bashtrykov P, Jeltsch A. Amplicon-Based Bisulfite Conversion-NGS DNA Methylation Analysis Protocol. Methods Mol. Biol. 2841, 405-418 (2024) PubMed Link
Kouroukli AG, Rajaram N, Bashtrykov P, Kretzmer H, Siebert R, Jeltsch A, Bens S. (2023) Targeting oncogenic TERT promoter variants by Allele-Specific Epigenome Editing. Clinical Epigenetics, 15(1):183. PMID: 37993930
Helm M, Bohnsack MT, Carell T, Dalpke A, Entian K-D, Ehrenhofer-Murray A, Ficner R, Hammann C, Höbartner C, Jäschke A, Jeltsch A, Kaiser S, Klassen R, Leidel SA, Marx A, Mörl M, Meier JC, Meister G, Rentmeister A, Rodnina M, Roignant J-Y, Schaffrath R, Stadler P, Stafforst T. (2023) Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications. ACS Chemical Biology 18(12):2441–2449. PMID: 37962075
Rajaram N, Kouroukli AG, Bens S, Bashtrykov P, Jeltsch A. (2023) Development of super-specific epigenome editing by targeted allele-specific DNA methylation. Epigenetics & Chromatin 16(1):41. PMID: 37864244
Kublanovsky M, Ulu GT, Weirich S, Levy N, Feldman M, Jeltsch A*, Levy D*. (2023) Methylation of the transcription factor E2F1 by SETD6 regulates SETD6 expression via a positive feedback mechanism. J. Biol. Chem., 299, 105236 . PMID: 37690684
Choudalakis M, Kungulovski G, Mauser R, Bashtrykov P, Jeltsch A. (2023) Refined read-out: The hUHRF1 Tandem-Tudor domain prefers binding to histone H3 tails containing K4me1 in the context of H3K9me2/3. Protein Science 32(9):e4760. PMID: 37593997
Weirich S, Jeltsch A. (2023) Limited choice of natural amino acids as mimetics restricts design of protein lysine methylation studies. Nature Communications 14:4097. PMID: 37433789
Adam S, Klingel V, Radde NE, Bashtrykov P, Jeltsch A. (2023) On the accuracy of the epigenetic copy machine: comprehensive specificity analysis of the DNMT1 DNA methyltransferase. Nucleic Acids Res. 51, 6622-6633. PMID: 37246710
Kouroukli AG, Fischer A, Kretzmer H, Chteinberg E, Rajaram N, Glaser S, Kolarova J, Bashtrykov P, Mathas S, Drexler H, Ohno H, Ammerpohl O, Jeltsch A, Siebert R, & Bens, S. (2023) The DNA methylation status of the TERT promoter differs between subtypes of mature B-cell lymphomas. Blood Cancer Journal 13, 98. PMID: 37365157
Toubhans B, Alkafri N, Quintela M, James DW, Bissardon C, Gazze S, Knodel F, Proux O, Gourlan AT, Rathert P, Bohic S, Gonzalez D, Francis LW, Charlet L, Conlan RS (2023) Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion. Redox Biol. 61, 102641. PMID: 36842241
Khella MS, Schnee P, Weirich S, Bui T, Bröhm A, Bashtrykov P, Pleiss J, Jeltsch A. (2023) The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation. J Biol Chem. 299, 104796. PMID: 37150325
Kunert S, Emperle M, Adam S, Dukatz M, Rajavelu A, Jeltsch A. (2023) The R736H cancer mutation in DNMT3A modulates the properties of the FF subunit interface. Biochimie 208, 66-74. PMID: 36528185
Graf D, Laistner L, Klingel V, Radde NE, Weirich S, Jeltsch A. (2023) Reversible switching and stability of the epigenetic memory system in bacteria. FEBS J. 290, 2115-2126. PMID: 36416580
Broche J, Köhler AR, Kühnel F, Osteresch B, Chandrasekaran TT, Adam S, Brockmeyer J, Jeltsch A. (2023) Genome-wide deposition of 6-methyladenine in human DNA reduces the viability of HEK293 cells and directly influences gene expression. Communications Biology 6, 1380. PMID: 36732350
Kunert S, Linhard V, Weirich S, Choudalakis M, Osswald F, Krämer L, Köhler AR, Bröhm A, Wollenhaupt J, Schwalbe H, Jeltsch A. (2023) The MECP2-TRD domain interacts with the DNMT3A-ADD domain at the H3-tail binding site. Protein Science 32(1), e4542. PMID: 36519786
Bashtrykov P, Rajaram N, Jeltsch, A. (2023) Efficient Targeted DNA Methylation with dCas9-Coupled DNMT3A-DNMT3L Methyltransferase. Methods Mol Biol. 2577, 177-188. PMID: 36173573
Li Y, Zhao Y, Yan X, Ye C, Weirich S, Zhang B, Wang X, Song L, Jiang C, Jeltsch A, Dong C, Mi W. (2022) CRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation. Nat Commun. 13(1):7636. PMID: 36496439.
Schnee P, Choudalakis M, Weirich S, Khella MS, Carvalho H, Pleiss J, Jeltsch A (2022) Mechanistic basis of the increased methylation activity of the SETD2 protein lysine methyltransferase towards a designed super-substrate peptide. Communications Chemistry 5, 139. Publisher Link
Jurkowska RZ, Jeltsch A. (2022) Enzymology of Mammalian DNA Methyltransferases. Adv Exp Med Biol. 1389, 69-110. PMID: 36350507
Jurkowska RZ, Jeltsch A. (2022) Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges. Adv Exp Med Biol. 1389, 1-19. PMID: 36350504
Dukatz M, Dittrich M, Stahl E, Adam S, de Mendoza A, Bashtrykov P, Jeltsch A. (2022) DNA methyltransferase DNMT3A forms interaction networks with the CpG site and flanking sequence elements for efficient methylation. J. Biol. Chem. 298(10), 102462. PMID: 36067881
Klingel V, Graf D, Weirich S, Jeltsch A, Radde NE. (2022) Model-Based Design of a Synthetic Oscillator Based on an Epigenetic Methylation Memory System. ACS Synth Biol. 11, 2445-2455. PMID: 35749318
Weirich S, Jeltsch A. (2022) Specificity Analysis of Protein Methyltransferases and Discovery of Novel Substrates Using SPOT Peptide Arrays. Methods Mol Biol 2529, 313-325. PMID: 35733022
Erdmann D, Contreras J, Le Meur RA, Vitorge B, Saverat V, Tafit A, Jallet C, Cadet-Daniel V, Bon C, Phansavath P, Ratovelomanana-Vidal V, Jeltsch A, Vichier-Guerre S, Guijarro JI, Arimondo PB (2022) Identification of Chemical Probes Targeting MBD2. ACS Chem Biol, 17:1415-1426. PMID: 35649238
Bröhm A, Schoch T, Grünberger D, Khella MS, Schuhmacher MK, Weirich S, Jeltsch A (2022) The H3.3 G34W oncohistone mutation increases K36 methylation by the protein lysine methyltransferase NSD1. Biochimie, 198:86-91. PMID 35341929
Dhayalan A, Albert Jeltsch A (2022) Special Issue "Structure, Activity, and Function of Protein Methyltransferases". Life (Basel) 12(3):405. PMID: 35330156
Bröhm A, Schoch T, Dukatz M, Graf N, Dorscht F, Mantai E, Adam S, Bashtrykov P, Jeltsch A (2022) Methylation of recombinant mononucleosomes by DNMT3A demonstrates efficient linker DNA methylation and a role of H3K36me3. Communications Biology, 5:192. Publisher Link PMID: 35236925
Mack A, Emperle M, Schnee P, Adam S, Pleiss J, Bashtrykov P, Jeltsch A. (2022) Preferential self-interaction of DNA methyltransferase DNMT3A subunits containing the R882H cancer mutation leads to dominant changes of flanking sequence preferences. J Mol Biol., 434(7):167482. PMID: 35131259
Adam S , Bräcker J, Klingel V, Osteresch B, Radde NE, Brockmeyer J, Bashtrykov P, Jeltsch A (2022) Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns. Communications Biology, 5:92. Publisher Link PMID: 35075236
Moorthy NK, Seifert O, Eisler S, Weirich S, Kontermann R, Rehm M, Gavin Fullstone G (2021) Low level endothelial TRAIL-receptor expression obstructs the CNS-delivery of Angiopep-2 functionalised TRAIL-receptor agonists for the
treatment of Glioblastoma. Molecules, 26:7582. PMID: 34946664
Jeltsch A, Adam S, Dukatz M, Emperle M, Bashtrykov P. (2021) Deep enzymology studies on DNA methyltransferases reveal novel connections between flanking sequences and enzyme activity. J. Mol. Biol., 433(19):167186. PMID: 34375615
Diesch J, Le Pannérer MM, Winkler R, Casquero R, Muhar M, van der Garde M, Maher M, Herráez CM, Bech-Serra JJ, Fellner M, Rathert P, Brooks N, Zamora L, Gentilella A, de la Torre C, Zuber J, Götze KS, Buschbeck M. (2021) Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis. Nat Commun., 12(1):6060. PMID: 34663789
Bauer TL, Collmar K, Kaltofen T, Loeffler AK, Decker L, Mueller J, Pinter S, Eisler SA, Mahner S, Fraungruber P, Kommoss S, Staebler A, Francis L, Conlan RS, Zuber J, Jeschke U, Trillsch F, Rathert P. (2021) Functional Analysis of Non-Genetic Resistance to Platinum in Epithelial Ovarian Cancer Reveals a Role for the MBD3-NuRD Complex in Resistance Development. Cancers (Basel) 13(15):3801. PMID: 34359703
Emperle M, Bangalore DM, Adam S, Kunert S, Heil HS, Heinze KG, Bashtrykov P, Tessmer I, Jeltsch A. (2021) Structural and biochemical insight into the mechanism of dual CpG site binding and methylation by the DNMT3A DNA methyltransferase. Nucleic Acids Res, 49(14):8294-308. PMID: 34289056
Rathert P (2021) Structure, Activity and Function of the NSD3 Protein Lysine Methyltransferase. Life, 11(8):726. PMID: 34440470
Weirich S, Khella MS, Jeltsch A (2021) Structure, Activity and Function of the Suv39h1 and Suv39h2 Protein Lysine Methyltransferases. Life, 11(7):703. PMID: 34357075
Balan S, Iwayama Y, Ohnishi T, Fukuda M, Shirai A, Yamada A, Weirich S, Schuhmacher MK, Dileep KV, Endo T, Hisano Y, Kotoshiba K, Toyota T, Otowa T, Kuwabara H, Tochigi M, Watanabe A, Ohba H, Maekawa M, Toyoshima M, Sasaki T, Nakamura K, Tsujii M, Matsuzaki H, Zhang KYJ, Jeltsch A, Shinkai Y, Yoshikawa T. (2021) A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain. Mol Psychiatry, 26(12):7550-7559. PMID: 34262135
Pinter S, Knodel F, Choudalakis M, Schnee P, Kroll C, Fuchs M, Broehm A, Weirich S, Roth M, Eisler SA, Zuber J, Jeltsch A, Rathert P. (2021) A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation. Nucleic Acids Res., 49(8):4350-4370. PMID: 33823549
Fraungruber P, Kaltofen T, Heublein S, Kuhn C, Mayr D, Burges A, Mahner S, Rathert P, Jeschke U, Trillsch F. (2021) G Protein-Coupled Estrogen Receptor Correlates With Dkk2 Expression and Has Prognostic Impact in Ovarian Cancer Patients. Front Endocrinol. 12:564002. PMID: 33679613
Klingel V, Kirch J, Ullrich T, Weirich S, Jeltsch A, Radde NE. (2021) Model-based robustness and bistability analysis for methylation-based, epigenetic memory systems. FEBS J., 288, 5692-5707. PMID: 33774905
Davydova E, Shimazu T, Schuhmacher MK, Jakobsson ME, Willemen HLDM, Liu T, Moen A, Ho AYY, Małecki J, Schroer L, Pinto R, Suzuki T, Grønsberg IA, Sohtome Y, Akakabe M, Weirich S, Kikuchi M, Olsen JV, Dohmae N, Umehara T, Sodeoka M, Siino V, McDonough M, Eijkelkamp N, Schofield CJ, Jeltsch A, Shinkai Y, Falnes PO. (2021) The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Nature Communications, 12:891. PMID: 33563959
Broche J, Kungulovski G, Bashtrykov P, Rathert P, Jeltsch A. (2021) Genome-wide investigation of the dynamic changes of epigenome modifications after global DNA methylation editing. Nucleic Acids Res. 49(1):158-176. PMID: 33300025
Khella MS, Bröhm A, Weirich S, Jeltsch A. (2020) Mechanistic Insights into the Allosteric Regulation of the Clr4 Protein Lysine Methyltransferase by Autoinhibition and Automethylation. Int J Mol Sci. 21(22):E8832. PMID: 33266419
Kaeswurm JAH, Nestl B, Richter SM, Emperle M, Buchweitz M. (2020) Purification and Characterization of Recombinant Expressed Apple Allergen Mal d 1. Methods Protoc 4(1):E3. PMID: 33375510
Dukatz M, Adam S, Biswal M, Song J, Bashtrykov P, & Jeltsch A.* (2020) Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase. Nucl. Acids Res. 48:11495-11509. PMID: 33105482
Lutsik P, Baude A, Mancarella D, Öz S, Kühn A, Toth R, Hey J, Toprak UH, Lim J, Nguyen VH, Jiang C, Mayakonda A, Hartmann M, Rosemann F, Breuer K, Vonficht D, Grünschläger F, Lee S, Schuhmacher MK, Kusevic D, Jauch A, Weichenhan D, Zustin J, Schlesner M, Haas S, Park JH, Park YJ, Oppermann U, Jeltsch A, Haller F, Fellenberg J, Lindroth AM, & Plass C. (2020) Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone. Nature Communications 11, 5414. PMID: 33110075
Schuhmacher MK, Beldar S, Khella MS, Bröhm A, Ludwig J, Tempel W, Weirich S, Min J, Jeltsch A. (2020) Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate. Communications Biology 3, 511. PMID: 32939018
Adam S, Anteneh H, Hornisch M, Wagner V, Lu J, Radde NE, Bashtrykov P, Song J, Jeltsch A. (2020) DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation. Nature communications 11:3723. PMID: 32709850
Gao L, Emperle M, Guo Y, Grimm SA, Ren W, Adam S, Uryu H, Zhang ZM, Chen D, Yin J, Dukatz M, Anteneh H, Jurkowska RZ, Lu J, Wang Y, Bashtrykov P, Wade PA, Wang GG, Jeltsch A, Song J. (2020) Comprehensive Structure-Function Characterization of DNMT3B and DNMT3A Reveals Distinctive De Novo DNA Methylation Mechanisms. Nature communications 11:3355. PMID: 32620778
Dong C, Chen SJ, Melnykov A, Weirich S, Sun K, Jeltsch A, Varshavsky A, Min J. (2020) Recognition of nonproline N-terminal residues by the Pro/N-degron pathway. Proc Natl Acad Sci U S A 117(25):14158-14167. PMID: 32513738
Ullrich T, Weirich S, Jeltsch A. (2020) Development of an epigenetic tetracycline sensor system based on DNA methylation. PLoS One 15(5):e0232701. PMID: 32379807
Stöhr D, Jeltsch A, Rehm M. (2020) TRAIL receptor signaling: From the basics of canonical signal transduction toward its entanglement with ER stress and the unfolded protein response. Int Rev Cell Mol Biol. 351:57-99.
PMID: 32247582
Jeltsch A & Gowher H. (eds). Role of DNA Methyltransferases in the Epigenome. (2020) Publisher: MDPI, Basel, ISBN: 978-3-03928-020-9 and 978-3-03928-021-6, DOI: 10.3390/books978-3-03928-021-6. Publisher-Link
Jeltsch A, Broche J, Lungu C, Bashtrykov P. (2020) Biotechnological Applications of MBD Domain Proteins for DNA Methylation Analysis. J Mol Biol. 432, 1816-32. PMID: 31493411
Hofacker D, Broche J, Laistner L, Adam S, Bashtrykov P, Jeltsch A. (2020) Engineering of Effector Domains for Targeted DNA Methylation with Reduced Off-Target Effects. Int J Mol Sci. 21(2):502. PMID: 31941101
Weirich S, Schuhmacher MK, Kudithipudi S, Lungu C, Ferguson AD, Jeltsch A. (2020) Analysis of the substrate specificity of the SMYD2 protein lysine methyltransferase and discovery of novel non-histone substrates. Chembiochem 21(1-2):256-264. Highlighted by the publisher as "Very Important Paper". PMID: 31612581
Dukatz M, Holzer K, Choudalakis M, Emperle M, Lungu C, Bashtrykov P, Jeltsch A. (2019) H3K36me2/3 binding and DNA binding of the DNA methyltransferase DNMT3A PWWP domain both contribute to its chromatin interaction. J Mol Biol. 431, 5083-5074. PMID: 31634469
Emperle M, Adam S, Kunert S, Dukatz M, Baude A, Plass C, Rathert P, Bashtrykov P, Jeltsch A. (2019) Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns. Nucl. Acids Res. 47, 11355-367. PMID: 31620784
Bröhm A, Elsawy H, Rathert P, Kudithipudi S, Schoch T, Schuhmacher MK, Weirich S, Jeltsch A. (2019) Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate Its Catalytic Activity. J Mol Biol. 431, 3068-3080. PMID: 31255706
Dukatz M, Requena CE, Emperle M, Hajkova P, Sarkies P, Jeltsch A. (2019) Mechanistic Insights into Cytosine-N3 Methylation by DNA Methyltransferase DNMT3A. J Mol Biol. 431, 3139-3145. PMID: 31229457
Daum R, Brauchle EM, Berrio DAC, Jurkowski TP, Schenke-Layland K. (2019) Non-invasive detection of DNA methylation states in carcinoma and pluripotent stem cells using Raman microspectroscopy and imaging. Sci Rep. 9(1):7014. PMID: 31065074
Sdelci S, Rendeiro AF, Rathert P, You W, Lin JG, Ringler A, Hofstätter G, Moll HP, Gürtl B, Farlik M, Schick S, Klepsch F, Oldach M, Buphamalai P, Schischlik F, Májek P, Parapatics K, Schmidl C, Schuster M, Penz T, Buckley DL, Hudecz O, Imre R, Wang SY, Maric HM, Kralovics R, Bennett KL, Müller AC, Mechtler K, Menche J, Bradner JE, Winter GE, Klavins K, Casanova E, Bock C, Zuber J, Kubicek S. (2019) THFD1 interaction with BRD4 links folate metabolism to transcriptional regulation. Nat Genet. 51(6):990-998. PMID: 31133746
Jeltsch A, Gowher H. (2019) Editorial-Role of DNA Methyltransferases in the Epigenome. Genes (Basel) 10, E574. PMID: 31366147
Jeltsch A. (2019) Novel Insights into Peptide Binding and Conformational Dynamics of UHRF1. Structure 27(3):408-410. PMID: 30840873
Li Z, Jiao X, Di Sante G, Ertel A, Casimiro MC, Wang M, Katiyar S, Ju X, Klopfenstein DV, Tozeren A, Dampier W, Chepelev I, Jeltsch A, Pestell RG. (2019) Cyclin D1 integrates G9a-mediated histone methylation. Oncogene 38(22):4232-4249. PMID: 30718920
Hipp K, Zikeli K, Kepp G, Schmid L, Shoeman RL, Jurkowski TP, Kleinow T, Jeske H. (2019) Different forms of African cassava mosaic virus capsid protein within plants and virions. Virology. 529:81-90. PMID: 30684693
Oberacker P, Stepper P, Bond DM, Höhn S, Focken J, Meyer V, Schelle L, Sugrue VJ, Jeunen GJ, Moser T, Hore SR, von Meyenn F, Hipp K, Hore TA, Jurkowski TP. (2019) Bio-On-Magnetic-Beads (BOMB): Open platform for high-throughput nucleic acid extraction and manipulation. PLoS Biol. 17(1):e3000107. PMID: 30629605
Mauser R, Jeltsch A. (2019) Application of modified histone peptide arrays in chromatin research. Arch Biochem Biophys. 661:31-38. PMID: 30391375
Jeltsch A, Broche J, Bashtrykov P. (2018) Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes. Genes 9(11):E566. PMID: 30469440
Menssen R, Bui K, Wolf DH. (2018) Regulation of the Gid ubiquitin ligase recognition subunit Gid4. FEBS Lett. 592(19):3286-3294. PMID: 30136317
Emperle M, Dukatz M, Kunert S, Holzer K, Rajavelu A, Jurkowska RZ, Jeltsch A. (2018) The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes. Sci Rep. 8:13242. PMID: 30185810
Maier JAH, Jeltsch A. (2018) Design and Application of 6mA-Specific Zinc-Finger Proteins for the Readout of DNA Methylation. Methods Mol Biol. 1867:29-41. PMID: 30155813
Gowher H, Jeltsch A. (2018) Mammalian DNA methyltransferases: new discoveries and open questions. Biochem Soc Trans. 46:1191-1202. PMID: 30154093
Jakobsson ME, Małecki JM, Halabelian L, Nilges BS, Pinto R, Kudithipudi S, Munk S, Davydova E, Zuhairi FR, Arrowsmith CH, Jeltsch A, Leidel SA, Olsen JV, Falnes PØ. (2018) The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates. Nat Commun. 9(1):3411. PMID: 30143613
Rajavelu A, Lungu C, Emperle M, Dukatz M, Bröhm A, Broche J, Hanelt I, Parsa E, Schiffers S, Karnik R, Meissner A, Carell T, Rathert P, Jurkowska RZ, Jeltsch A. (2018) Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2. Nucleic Acids Res. 46:9044-56. Journal-Link PMID: 30102379
Schwenger A, Jurkowski TP, Richert C. (2018) Capturing and Stabilizing Folded Proteins in Lattices Formed with Branched Oligonucleotide Hybrids. Chembiochem 19:1523-30. PMID: 29888515
Wolf DH, Menssen R. Mechanisms of cell regulation - proteolysis, the big surprise. FEBS Lett.592:2515-2524. PMID: 29790175
Schuhmacher MK, Rolando M, Bröhm A, Weirich S, Kudithipudi S, Buchrieser C, Jeltsch A. (2018) The Legionella pneumophila Methyltransferase RomA Methylates Also Non-histone Proteins during Infection. J Mol Biol. 430(13):1912-1925. PMID: 29733858
Halby L, Marechal N, Pechalrieu D, Cura V, Franchini DM, Faux C, Alby F, Troffer-Charlier N, Kudithipudi S, Jeltsch A, Aouadi W, Decroly E, Guillemot JC, Page P, Ferroud C, Bonnefond L, Guianvarc'h D, Cavarelli J, Arimondo PB (2018) Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors. Philos Trans R Soc Lond B Biol Sci. 373(1748). pii: 20170072. PMID: 29685976
Emperle M, Rajavelu A, Kunert S, Arimondo PB, Reinhardt R, Jurkowska RZ, Jeltsch A. (2018) The DNMT3A R882H mutant displays altered flanking sequence preferences. Nucleic Acids Res. 46(6):3130-3139. PMID: 29518238
Rots MG, Jeltsch A. (2018) Editing the Epigenome: Overview, Open Questions, and Directions of Future Development. Methods Mol Biol. 1767:3-18. PMID: 29524127
Bashtrykov P, Jeltsch A. (2018) Allele-Specific Epigenome Editing. Methods Mol Biol. 1767:137-146. PMID: 29524132
Kroll C, Rathert P. (2018) Stable Expression of Epigenome Editors via Viral Delivery and Genomic Integration. Methods Mol Biol. 1767:215-225. PMID: 29524137
Bashtrykov P, Jeltsch A. (2018) DNA Methylation Analysis by Bisulfite Conversion Coupled to Double Multiplexed Amplicon-Based Next-Generation Sequencing (NGS). Methods Mol Biol. 1767:367-382. PMID: 29524146
Rošić S, Amouroux R, Requena CE, Gomes A, Emperle M, Beltran T, Rane JK, Linnett S, Selkirk ME, Schiffer PH, Bancroft AJ, Grencis RK, Jeltsch A, Hajkova P, Sarkies P (2018) Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity. Nature Genetics 50(3):452-459. Link to the article
Jeltsch A, Rots MG (editors) Epigenome Editing - Methods and Protocols. Series: Methods in Moleclar Biology (Volume 1767), DOI: 10.1007/978-1-4939-7774-1, Hardcover ISBN: 978-1-4939-7773-4, Publisher Springer International Publishing, 588 pages, publication date: March 27, 2018. Link to the book
Berner N, Reutter KR, Wolf DH (2018) Protein Quality Control of the Endoplasmic Reticulum and Ubiquitin-Proteasome-Triggered Degradation of Aberrant Proteins: Yeast Pioneers the Path. Annu Rev Biochem 87:751-782. PMID: 29394096
Rawłuszko-Wieczorek AA, Knodel F, Tamas R, Dhayalan A, Jeltsch A (2018) Identification of protein lysine methylation readers with a yeast three-hybrid approach. Epigenetics & Chromatin 11(1):4. PMID: 29370823
Jeltsch A (2018) From bioengineering to CRISPR/Cas9-a personal retrospective of 20 years of research in programmable genome targeting. Frontiers in Genetics 9:5. Link to publication
Hohenstatt ML, Mikulski P, Komarynets O, Klose C, Kycia I, Jeltsch A, Farrona S, Schubert D (2018) PWWP-DOMAIN INTERACTOR OF POLYCOMBS11 interacts with Polycomb-group proteins and histones and regulates Arabidopsis flowering and development. Plant Cell 30(1):117-133. PMID: 29330200
Mauser R, Kungulovski G, Meral D, Maisch D, Jeltsch A (2018) Application of mixed peptide arrays to study combinatorial readout of chromatin modifications. Biochimie 146:14-19. PMID: 29133117
Ravichandran M, Jurkowska RZ, Jurkowski TP (2018) Target specificity of mammalian DNA methylation and demethylation machinery. Org Biomol Chem 16(9):1419-1435. PMID: 29265160
Weirich S & Jeltsch A (2017) Mutations in Histone Lysine Methyltransferases and Demethylases. Reference Module in Biomedical Sciences, Elsevier. Link to the article
Jurkowska RZ, Qin S, Kungulovski G, Tempel W, Liu Y, Bashtrykov P, Stiefelmaier J, Jurkowski TP, Kudithipudi S, Weirich S, Tamas R, Wu H, Dombrovski L, Loppnau P, Reinhardt R, Min J, Jeltsch A (2017) H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1. Nat Commun. 8(1):2057. PMID: 29234025
Imre L, Simándi Z, Horváth A, Fenyőfalvi G, Nánási P, Niaki EF, Hegedüs É, Bacsó Z, Weyemi U, Mauser R, Ausio J, Jeltsch A, Bonner W, Nagy L, Kimura H, Szabó G (2017) Nucleosome stability measured in situ by automated quantitative imaging. Sci Rep. 7(1):12734. PMID: 28986581
Mauser R, Kungulovski G, Keup C, Reinhardt R, Jeltsch A (2017) Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state. Epigenetics Chromatin. 10(1):45. PMID: 28946896
Saunderson EA, Stepper P, Gomm JJ, Hoa L, Morgan A, Allen MD, Jones JL, Gribben JG, Jurkowski TP, Ficz G (2017) Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors. Nat Commun. 2017 Nov 13;8(1):1450. PMID: 29133799
Lungu C, Pinter S, Broche J, Rathert P, Jeltsch A (2017) Modular fluorescence complementation sensors for live cell detection of epigenetic signals at endogenous genomic sites. Nat Commun. 8(1):649. PMID: 28935858
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LABOonline - Epigenetische Informationen aus lebenden Zellen gewinnen Link
Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y, Defossez PA (2017) Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation. Mol Cell, 67(4):550-565. PMID: 28803780
Engmann O, Labonté B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh YE, Walker DM, Burek D, Hamilton PJ, Issler O, Neve RL, Turecki G, Hurd Y, Chess A, Shen L, Mansuy I, Jeltsch A, Akbarian S, Nestler EJ (2017) Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2. Biol Psychiatry, 82(11):794-805. PMID: 28577753
Maier JAH, Möhrle R, Jeltsch A (2017) Design of synthetic epigenetic circuits featuring memory effects and reversible switching based on DNA methylation. Nat Commun. 8:15336. PMID: 28537256
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Rusk N (2017) Synthetic biology: Synthetic epigenetic memory. Nat. Methods 14, 764-765. Journal Link
Tuzman KT (2017) Synthetic record. Biocentury Innovations, Translation in Brief, Jul 13. Journal Link
Bashtrykov P, Jeltsch A (2017) Epigenome Editing in the Brain. Adv Exp Med Biol. 978:409-424. PMID: 28523558
Song J, Cano-Rodriquez D, Winkle M, Gjaltema RA, Goubert D, Jurkowski TP, Heijink IH, Rots MG, Hylkema MN (2017) Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 312(3):L334-L347. PMID: 28011616
Weirich S, Kudithipudi S, Jeltsch A (2017) Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex. Mol Oncol. 11:373-387. PMID: 28182322
Kudithipudi S, Schuhmacher MK, Kebede AF, Jeltsch A (2017) The SUV39H1 Protein Lysine Methyltransferase Methylates Chromatin Proteins Involved in Heterochromatin Formation and VDJ Recombination. ACS Chem Biol. 12:958-968. PMID: 28169523
Kusevic D, Kudithipudi S, Iglesias N, Moazed D, Jeltsch A (2017) Clr4 specificity and catalytic activity beyond H3K9 methylation. Biochimie 135:83-88. PMID: 28143796
Stepper P, Kungulovski G, Jurkowska RZ, Chandra T, Krueger F, Reinhardt R, Reik W, Jeltsch A, Jurkowski TP (2017) Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase. Nucleic Acids Res. 45:1703-13. PMID: 27899645
Kaiser S, Jurkowski TP, Kellner S, Schneider D, Jeltsch A, Helm M (2016) The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA. RNA Biol. 14(9):1241-1251. PMID: 27819523
Jeltsch A, Ehrenhofer-Murray A, Jurkowski T, Lyko F, Reuter G, Ankri S, Nellen W, Schaefer M, Helm M. (2016) Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation. RNA Biol. 14(9):1108-1123. PMID: 27232191
Jurkowska RZ, Jeltsch A (2016) Enzymology of Mammalian DNA Methyltransferases. Adv Exp Med Biol. 945:87-122. PMID: 27826836
Jurkowska RZ, Jeltsch A (2016) Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges. Adv Exp Med Biol. 945:1-17. PMID: 27826832
Kudithipudi S, Jeltsch A (2016) Approaches and Guidelines for the Identification of Novel Substrates of Protein Lysine Methyltransferases. Cell Chem Biol. 23(9):1049-55. PMID: 27569752
Jeltsch A, Jurkowska RZ (2016) Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm. Nucleic Acids Res. 44(18):8556-8575. PMID: 27521372
Hore TA, von Meyenn F, Ravichandran M, Bachman M, Ficz G, Oxley D, Santos F, Balasubramanian S, Jurkowski TP, Reik W (2016) Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms. Proc Natl Acad Sci U S A. 113(43):12202-12207. PMID: 27729528
Schuhmacher MK, Kudithipudi S, Jeltsch A. (2016) Investigation of H2AX methylation by the SUV39H2 protein lysine methyltransferase. FEBS Lett. 590(12):1713-9. PMID: 27177470
Amm I, Wolf DH. (2016) Molecular mass as a determinant for nuclear San1-dependent targeting of misfolded cytosolic proteins to proteasomal degradation. FEBS Lett. 590(12):1765-75. PMID: 27173001
Weirich S, Kudithipudi S, Jeltsch A. (2016) Specificity of the SUV4-20H1 and SUV4-20H2 protein lysine methyltransferases and methylation of novel substrates. J Mol Biol. 2016 428(11):2344-58. PMID: 27105552
Kungulovski G, Mauser R, Reinhardt R, Jeltsch A. (2016) Application of recombinant TAF3 PHD domain instead of anti-H3K4me3 antibody. Epigenetics Chromatin 22,9:11. PMID: 27006701
Lukashevich OV, Cherepanova NA, Jurkovska RZ, Jeltsch A, Gromova ES. (2016) Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity. BMC Biochem. 17:7. PMID: 27001594
Kusevic D, Kudithipudi S, Jeltsch A. (2016) Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates. J Biol Chem. 291(12):6124-33. PMID: 26797129
Bashtrykov P, Kungulovski G, Jeltsch A (2016) Correction of aberrant imprinting by allele specific epigenome editing. Clin Pharmacol Ther. 99(5):482-4. PMID: 26537177
Kungulovski G, Jeltsch A. (2016) Epigenome Editing: State of the Art, Concepts, and Perspectives. Trends Genet. 32(2):101-113. PMID: 26732754
Hoenicka H, Lehnhardt D, Nunna S, Reinhardt R, Jeltsch A, Briones V, Fladung M (2016) Level of tissue differentiation influences the activation of a heat-inducible flower-specific system for genetic containment in poplar (Populus tremula L.). Plant Cell Rep. 35(2):369-84. PMID: 26521210
Amm I, Norell D, Wolf DH (2015) Absence of the Yeast Hsp31 Chaperones of the DJ-1 Superfamily Perturbs Cytoplasmic Protein Quality Control in Late Growth Phase. PLoS One 10(10):e0140363. PMID: 26466368
Pfirrmann T, Villavicencio-Lorini P, Subudhi AK, Menssen R, Wolf DH, Hollemann T (2015) RMND5 from Xenopus laevis is an E3 ubiquitin-ligase and functions in early embryonic forebrain development. PLoS One 10(3):e0120342. PMID: 25793641
Menssen R, Wolf DH (2015) Ubiquitin-Proteasom-gesteuerte Regulation und Qualitätskontrolle der Zelle. BIOspektrum 21(6): 608-611. Publisher Link
Kungulovski G and Jeltsch A (2015) Quality of histone modification antibodies undermines chromatin biology research. F1000Research 4:1160. Publisher Link
Patalano S, Vlasova A, Wyatt C, Ewels P, Camara F, Ferreira PG, Asher CL, Jurkowski TP, Segonds-Pichon A, Bachman M, González-Navarrete I, Minoche AE, Krueger F, Lowy E, Marcet-Houben M, Rodriguez-Ales JL, Nascimento FS, Balasubramanian S, Gabaldon T, Tarver JE, Andrews S, Himmelbauer H, Hughes WO, Guigó R, Reik W, Sumner S. (2015) Molecular signatures of plastic phenotypes in two eusocial insect species with simple societies. Proc Natl Acad Sci U S A. 112(45):13970-5. PMID: 26483466
Maier JA, Albu RF, Jurkowski TP, Jeltsch A (2015) Investigation of the C-terminal domain of the bacterial DNA-(adenine N6)-methyltransferase CcrM. Biochimie 119:60-7. PMID: 26475175
Kungulovski G, Kycia I, Mauser R, Jeltsch A (2015) Specificity Analysis of Histone Modification-Specific Antibodies or Reading Domains on Histone Peptide Arrays. Methods Mol Biol. 1348:275-84. PMID: 26424280
Weirich S, Kusevic D, Kudithipudi S, Jeltsch A (2015) Investigation of the methylation of Numb by the SET8 protein lysine methyltransferase. Sci Rep. 5:13813. PMID: 26391684
Delatte B, Jeschke J, Defrance M, Bachman M, Creppe C, Calonne E, Bizet M, Deplus R, Marroquí L, Libin M, Ravichandran M, Mascart F, Eizirik DL, Murrell A, Jurkowski TP, Fuks F. (2015) Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress. Sci Rep. 5:12714. PMID: 26239807
A Jeltsch, W Wende, P Friedhoff, BL Stoddard (2015) Editorial: Alfred Pingoud (1945–2015). Nucleic Acids Research 43 (16), 7661-7663. Publisher Link
Shanmugam R, Fierer J, Kaiser S, Helm M, Jurkowski TP, Jeltsch A (2015) Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences. Cell Discovery 1:15010. Publisher Link
Kungulovski G, Nunna S, Thomas M, Zanger UM, Reinhardt R, Jeltsch A (2015) Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained. Epigenetics Chromatin 8:12. PMID: 25901185
Subinya M, Steudle AK, Jurkowski TP, Stubenrauch C. (2015) Conformation and activity of lipase B from Candida antarctica in bicontinuous microemulsions. Colloids Surf B Biointerfaces. 131:108-14. PMID: 25973762
Weirich S, Kudithipudi S, Kycia I, Jeltsch A. (2015) Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme. Clin. Epigenetics 7(1), 36. PMID: 25829971
Voelcker-Rehage C, Jeltsch A, Godde B, Becker S, Staudinger UM (2015) COMT gene polymorphisms, cognitive performance, and physical fitness in older adults. Psychology of Sport and Exercise, 20, 230-28. Publisher Link
Lungu C, Muegge K, Jeltsch A, Jurkowska RZ (2015) An ATPase-deficient variant of the SNF2 family member HELLS shows altered dynamics at pericentromeric heterochromatin. J. Mol. Biol. 427(10), 1903-15. PMID: 25823553
Elhardt W, Shanmugam R, Jurkowski TP, Jeltsch A. (2015) Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties. Biochimie 112, 66-72. PMID: 25747896
Pfirrmann T, Villavicencio-Lorini P, Subudhi AK, Menssen R, Wolf DH, Hollemann T. (2015) RMND5 from Xenopus laevis Is an E3 Ubiquitin-Ligase and Functions in Early Embryonic Forebrain Development. PLOS One 10(3), e0120342. PMID: 25793641
Jurkowski TP, Ravichandran M, Stepper P (2015) Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity. Clin Epigenetics 7, 18. PMID: 25741388
Maier JAH, Ragozin S, Jeltsch A (2015) Identification, cloning and heterologous expression of active [NiFe]-hydrogenase 2 from Citrobacter sp. SG in Escherichia coli. J. Biotech. 199, 1-8. PMID: 25678135
Bashtrykov P, & Jeltsch A (2015) DNMT1-associated DNA methylation changes in cancer. Cell Cycle 14, 5. PMID: 25483051
Scazzari M, Amm I, Wolf DH (2015) Quality control of a cytoplasmic protein complex: Chaperone motors and the ubiquitin-proteasome system govern the fate of orphan fatty acid synthase subunit Fas2 of yeast. J. Biol. Chem. 290, 4677-87. PMID: 25564609
Schuhmacher MK, Kudithipudi S, Kusevic D, Weirich S, & Jeltsch A (2015) Activity and specificity of the human SUV39H2 protein lysine methyltransferase. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1849(1):55-63. PMID: 25459750
Link to the JoVE Video @ Uni Stuttgart
Kungulovski G, Kycia I, Tamas R, Jurkowska RZ, Kudithipudi S, Henry C, Reinhardt R, Labhart P, & Jeltsch A. (2014) Application of histone modification-specific interaction domains as an alternative to antibodies. Genome Res. 24 (11), 1842-1853. PMID: 25301795
Emperle M, Rajavelu A, Reinhardt R, Jurkowska RZ, & Jeltsch A (2014) Cooperative DNA binding and protein/DNA fiber formation increases the activity of the Dnmt3a DNA methyltransferase. J. Biol. Chem. 289 (43), 29602-29613. PMID: 25147181
Kudithipudi S, & Jeltsch A (2014) Role of somatic cancer mutations in human protein lysine methyltransferases. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1846(2):366-379 PMID: 25123655
Deplus R, Blanchon L, Rajavelu A, Boukaba A, Defrance M, Luciani J, Rothé F, Dedeurwaerder S, Denis H, Brinkman AB, Simmer F, Müller F, Bertin B, Berdasco M, Putmans P, Calonne E, Litchfield DW, de Launoit Y, Jurkowski TP, Stunnenberg HG, Bock C, Sotiriou C, Fraga MF, Esteller M, Jeltsch A & Fuks F. (2014) Regulation of DNA Methylation Patterns by CK2-Mediated Phosphorylation of Dnmt3a. Cell Reports 8(3):743-53 PMID: 25066127
Jeltsch A & Jurkowska RZ (2014) New concepts in DNA methylation. Trends Biochem Sci. 39, 310-18. PMID: 24947342
Guitot K, Scarabelli S, Drujon T, Bolbach G, Amoura M, Burlina F, Jeltsch A, Sagan S, Guianvarc'h D (2014) Label-free measurement of histone lysine methyltransferases activity by MALDI-TOF mass spectrometry. Analytical Biochem. 456:25-31 PMID: 24747023
Shanmugam R, Aklujkar M, Schäfer M, Reinhardt R, Nickel O, Reuter G, Lovley DR, Ehrenhofer-Murray A, Nellen W, Ankri S, Helm M, Jurkowski TP, & Jeltsch A.(2014) The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu. Nucl. Acids Res. 42(10):6487-96 PMID: 24711368
Rilova E, Erdmann A, Gros C, Masson V, Aussagues Y, Poughon-Cassabois V, Rajavelu A, Jeltsch A, Menon Y, Novosad N, Gregoire JM, Vispé S, Schambel P, Ausseil F, Sautel F, Arimondo PB, Cantagrel F.(2014) Design, Synthesis and Biological Evaluation of 4-Amino-N-(4-aminophenyl)benzamide Analogues of Quinoline-Based SGI-1027 as Inhibitors of DNA Methylation. ChemMedChem 9(3):590-601 PMID: 24678024
Bashtrykov P, Rajavelu A, Hackner B, Ragozin S, Carell T & Jeltsch A.(2014) Targeted Mutagenesis Results in an Activation of DNA Methyltransferase 1 and Confirms an Autoinhibitory Role of its RFTS Domain. ChemBioChem 15(5):743-8. PMID: 24532244
Nunna S, Reinhardt R, Ragozin S, Jeltsch A (2014) Targeted Methylation of the Epithelial Cell Adhesion Molecule (EpCAM) Promoter to Silence Its Expression in Ovarian Cancer Cells. PLoS One 9(1):e87703. PMID: 24489952
Kudithipudi S, Lungu C, Rathert P, Happel N & Jeltsch A (2014) Substrate Specificity Analysis and Novel Substrates of the Protein Lysine Methyltransferase NSD1. Chemistry & Biology 21(2):226-37. PMID: 24412544
Amm I, Sommer T, & Wolf DH (2014) Protein quality control and elimination of protein waste: The role of the ubiquitin-proteasome system. Biochim Biophys Acta. 1843(1):182-96. PMID: 23850760
Asgatay S, Champion C, Marloie G, Drujon T, Senamaud-Beaufort C, Ceccaldi A, Erdmann A, Rajavelu A, Schambel P, Jeltsch A, Lequin O, Karoyan P, Arimondo PB & Guianvarc'h D. (2014) Synthesis and Evaluation of Analogues of N-Phthaloyl-L-tryptophan (RG108) as Inhibitors of DNA Methyltransferase 1. J. Med. Chem. 57(2):421-34. PMID: 24328113
Bashtrykov P, Jankevicius G, Jurkowska RZ, Ragozin S, & Jeltsch A. (2014) The Uhrf1 protein stimulates the activity and specificity of the maintenance DNA methyltransferase Dnmt1 by an allosteric mechanism. J. Biol. Chem. 289(7), 4106-15. PMID: 24368767
Stolz A, Besser S, Hottmann H & Wolf DH(2013) Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation. PNAS 110, 15271-6. PMID: 23988329
Kycia I, Kudithipudi S, Tamas R, Kungulovski G, Dhayalan A, Jeltsch A (2013)The Tudor Domain of the PHD Finger Protein 1 Is a Dual Reader of Lysine Trimethylation at Lysine 36 of Histone H3 and Lysine 27 of Histone Variant H3t. J. Mol. Biol. 426(8):1651-60. PMID: 23954330
Müller S, Windhof IM, Maximov V, Jurkowski T, Jeltsch A, Förstner KU, Sharma CM, Gräf R, & Nellen W. (2013) Target recognition, RNA methylation activity and transcriptional regulation of the Dictyostelium discoideum Dnmt2-homologue (DnmA). Nucl. Acids Res. 41, 8615-27. PMID: 23877245
Kudithipudi, S., Kusevic, D., Jeltsch A. (2013) Non-radioactive Protein Lysine Methyltransferase Microplate Assay Based on Reading Domains. ChemMedChem 9(3):554-9. PMID: 23671032
Jeltsch A. & Jurkowska, R.Z. (2013) Multimerization of the Dnmt3a DNA Methyltransferase and its Functional Implications. Prog Mol Biol Transl Sci. 117, 445-64. PMID: 23663978
Jeltsch A. (2013) Oxygen, epigenetic signaling and the evolution of early life. Trends in Biochemical Sciences, 38(4):172-6. PMID: 23454078
Ceccaldi A, Rajavelu A, Ragozin S, Sénamaud-Beaufort C, Bashtrykov P, Testa N, Dali-Ali H, Maulay-Bailly C, Amand S, Guianvarc'h D, Jeltsch A, Arimondo PB. (2013) Identification of Novel Inhibitors of DNA Methylation by Screening of a Chemical Library. ACS Chem Biol. 8(3):543-8. PMID: 23294304
Siddique AN, Nunna S, Rajavelu A, Zhang Y, Jurkowska RZ, Reinhardt R, Rots MG, Ragozin S, Jurkowski TP, Jeltsch A. (2013) Targeted Methylation and Gene Silencing of VEGF-A in Human Cells by Using a Designed Dnmt3a-Dnmt3L Single-Chain Fusion Protein with Increased DNA Methylation Activity. J Mol Biol. 2013;425(3):479-91. PMID: 23220192
Fahy J, Jeltsch A, Arimondo PB. DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies. Expert Opin Ther Pat. 2012 Dec;22(12):1427-42. PMID: 23033952
Kutscher D, Pingoud A, Jeltsch A, Meiss G. Identification of ICAD-derived peptides capable of inhibiting caspase-activated DNase. FEBS J. 2012 Aug;279(16):2917-28. PMID: 22727028
Menssen R, Schweiggert J, Schreiner J, Kusevic D, Reuther J, Braun B, Wolf DH. Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. J Biol Chem. 2012 Jul 20;287(30):25602-14. doi: 10.1074/jbc.M112.363762. Epub 2012 May 29. PMID:22645139
Bashtrykov P, Ragozin S, Jeltsch A. Mechanistic details of the DNA recognition by the Dnmt1 DNA methyltransferase. FEBS Lett. 2012 Jun 21;586(13):1821-3. PMID: 22641038
Bashtrykov P, Jankevicius G, Smarandache A, Jurkowska RZ, Ragozin S, Jeltsch A. Specificity of Dnmt1 for methylation of hemimethylated CpG sites resides in its catalytic domain. Chem Biol. 2012;19(5):572-8. PMID: 22633409
Albu RF, Zacharias M, Jurkowski TP, Jeltsch A. DNA interaction of the CcrM DNA methyltransferase: a mutational and modeling study. Chembiochem. 2012 Jun 18;13(9):1304-11. PMID: 22639453
Jurkowski TP, Shanmugam R, Helm M, Jeltsch A.Mapping the tRNA binding site on the surface of human DNMT2 methyltransferase. Biochemistry. 2012 Jun 5;51(22):4438-44. PMID: 22591353
Kudithipudi S, Dhayalan A, Kebede AF, Jeltsch A.The SET8 H4K20 protein lysine methyltransferase has a long recognition sequence covering seven amino acid residues. Biochimie. 2012;94(11):2212-8. PMID: 22583696
Stolz A, Wolf DH. Use of CPY and its derivatives to study protein quality control in various cell compartments. Methods Mol Biol. 2012;832:489-504. PMID: 22350908
Florea M, Kudithipudi S, Rei A, González-Álvarez MJ, Jeltsch A, Nau WM. A fluorescence-based supramolecular tandem assay for monitoring lysine methyltransferase activity in homogeneous solution. Chemistry. 2012;18(12):3521-8. PMID: 22367964
Halby L, Champion C, Sénamaud-Beaufort C, Ajjan S, Drujon T, Rajavelu A, Ceccaldi A, Jurkowska R, Lequin O, Nelson WG, Guy A, Jeltsch A, Guianvarc'h D, Ferroud C, Arimondo PB. Rapid synthesis of new DNMT inhibitors derivatives of procainamide. Chembiochem. 2012;13(1):157-65. PMID: 22170584
Jurkowski TP, Jeltsch A. On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2. PLoS One. 2011;6(11):e28104. PMID: 22140515
Jeltsch A. Epigenetics Europe conference. Munich, Germany, 8-9 September 2011. Epigenomics. 2011;3(6):693-5. PMID: 22126289
Jurkowski TP, Jeltsch A. Burning off DNA methylation: new evidence for oxygen-dependent DNA demethylation. Chembiochem. 2011 Nov 25;12(17):2543-5. PMID: 21998074
Bonnist EY, Liebert K, Dryden DT, Jeltsch A, Jones AC. Using the fluorescence decay of 2-aminopurine to investigate conformational change in the recognition sequence of the EcoRV DNA-(adenine-N6)-methyltransferase on enzyme binding. Biophys Chem. 2012;160(1):28-34. PMID: 21962489
Rajavelu A, Jurkowska RZ, Fritz J, Jeltsch A. Function and disruption of DNA methyltransferase 3a cooperative DNA binding and nucleoprotein filament formation. Nucleic Acids Res. 2012;40(2):569-80. PMID: 21926161
Martinez Benitez E, Stolz A, Becher A, Wolf DH. Mnl2, a novel component of the ER associated protein degradation pathway. Biochem Biophys Res Commun. 2011;414(3):528-32. PMID: 21971548
Albu RF, Jurkowski TP, Jeltsch A. The Caulobacter crescentus DNA-(adenine-N6)-methyltransferase CcrM methylates DNA in a distributive manner.Nucleic Acids Res. 2012;40(4):1708-16. PMID: 21926159
Wolf DH, Stolz A. The Cdc48 machine in endoplasmic reticulum associated protein degradation. Biochim Biophys Acta. 2012;1823(1):117-24. PMID: 21945179
Jurkowska RZ, Ceccaldi A, Zhang Y, Arimondo PB, Jeltsch A. DNA methyltransferase assays. Methods Mol Biol. 2011;791:157-77. PMID: 21913079
Bock I, Kudithipudi S, Tamas R, Kungulovski G, Dhayalan A, Jeltsch A. Application of Celluspots peptide arrays for the analysis of the binding specificity of epigenetic reading domains to modified histone tails.BMC Biochem. 2011;12:48. PMID: 21884582
Benitez EM, Stolz A, Wolf DH. Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD. FEBS Lett. 2011;585(19):3015-9. PMID: 21871892
Wolf DH. The ubiquitin clan: A protein family essential for life. FEBS Lett. 2011;585(18):2769-71. PMID: 21867706
Ceccaldi A, Rajavelu A, Champion C, Rampon C, Jurkowska R, Jankevicius G, Sénamaud-Beaufort C, Ponger L, Gagey N, Ali HD, Tost J, Vriz S, Ros S, Dauzonne D, Jeltsch A, Guianvarc'h D, Arimondo PB.C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development. Chembiochem. 2011;12(9):1337-45. PMID: 21633996
Li BZ, Huang Z, Cui QY, Song XH, Du L, Jeltsch A, Chen P, Li G, Li E, Xu GL. Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase. Cell Res. 2011;21(8):1172-81. PMID: 21606950
Jurkowska RZ, Rajavelu A, Anspach N, Urbanke C, Jankevicius G, Ragozin S, Nellen W, Jeltsch A. Oligomerization and binding of the Dnmt3a DNA methyltransferase to parallel DNA molecules: heterochromatic localization and role of Dnmt3L. J Biol Chem. 2011;286(27):24200-7. PMID: 21566127
Stolz A, Hilt W, Buchberger A, Wolf DH. Cdc48: a power machine in protein degradation. Trends Biochem Sci. 2011;36(10):515-23. PMID: 21741246
Rajavelu A, Tulyasheva Z, Jaiswal R, Jeltsch A, Kuhnert N. The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols. BMC Biochem. 2011;12:16. PMID: 21510884
Siddique AN, Jurkowska RZ, Jurkowski TP, Jeltsch A. Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue. FEBS J. 2011;278(12):2055-63. PMID: 21481189
Dhayalan A, Tamas R, Bock I, Tattermusch A, Dimitrova E, Kudithipudi S, Ragozin S, Jeltsch A. The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9.Hum Mol Genet. 2011;20(11):2195-203. PMID: 21421568
Jurkowska RZ, Siddique AN, Jurkowski TP, Jeltsch A. Approaches to enzyme and substrate design of the murine Dnmt3a DNA methyltransferase. Chembiochem. 2011;12(10):1589-94. PMID: 21400651
Dhayalan A, Kudithipudi S, Rathert P, Jeltsch A. Specificity analysis-based identification of new methylation targets of the SET7/9 protein lysine methyltransferase. Chem Biol. 2011;18(1):111-20. PMID: 21276944
Jurkowska RZ, Jurkowski TP, Jeltsch A. Structure and function of mammalian DNA methyltransferases. Chembiochem. 2011;12(2):206-22. Review. PMID: 21243710
Jeltsch A, Fischle W. Molecular epigenetics: connecting human biology and disease with little marks. Chembiochem. 2011;12(2):183-4. PMID: 21243707
Bock I, Dhayalan A, Kudithipudi S, Brandt O, Rathert P, Jeltsch A. Detailed specificity analysis of antibodies binding to modified histone tails with peptide arrays. Epigenetics. 2011;6(2):256-63. PMID: 20962581 Eisele F, Schäfer A, Wolf DH. Ubiquitylation in the ERAD Pathway. Subcell Biochem. 2010;54:136-48. PMID: 21222279.
Stolz A, Schweizer RS, Schäfer A, Wolf DH. Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD. Traffic. 2010;11(10):1363-9. PMID: 20579315.
Champion C, Guianvarc'h D, Sénamaud-Beaufort C, Jurkowska RZ, Jeltsch A, Ponger L, Arimondo PB, Guieysse-Peugeot AL. Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine. PLoS One. 2010;5(8):e12388. PMID: 20808780.
Jurkowska RZ, Jeltsch A. Silencing of gene expression by targeted DNA methylation: concepts and approaches. Methods Mol Biol. 2010;649:149-61. PMID: 20680833.
Dhayalan A, Rajavelu A, Rathert P, Tamas R, Jurkowska RZ, Ragozin S, Jeltsch A. The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. J Biol Chem. 2010;285(34):26114-20. PMID: 20547484
Jeltsch A. Molecular biology. Phylogeny of methylomes. Science. 2010;328(5980):837-8. PMID: 20466912
Rohde C, Zhang Y, Reinhardt R, Jeltsch A. BISMA-fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences. BMC Bioinformatics. 2010;11:230. PMID: 20459626
Barbin L, Eisele F, Santt O, Wolf DH. The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase. Biochem Biophys Res Commun. 2010;394(2):335-41. PMID: 20206597.
Zhang Y, Jurkowska R, Soeroes S, Rajavelu A, Dhayalan A, Bock I, Rathert P, Brandt O, Reinhardt R, Fischle W, Jeltsch A. Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Res. 2010;38(13):4246-53. PMID: 20223770
Juretschke J, Menssen R, Sickmann A, Wolf DH. The Hsp70 chaperone Ssa1 is essential for catabolite induced degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase. Biochem Biophys Res Commun. 2010;397(3):447-52. PMID: 20513352
Jurkoska RZ, Jeltsch A. The Chemical Biology of Nucleic Acids In: Mayer G, editor. Chichester, UK: John Wiley & Sons, Ltd.; 2010. DNA Methylation. pp. 307-322.
Stolz A, Wolf DH. Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell. Biochim Biophys Acta. 2010;1803(6):694-705. Review. PMID: 20219571
Zhang Y, Jeltsch A. The Application of Next Generation Sequencing in DNA Methylation Analysis. Genes. 2010; 1(1):85-101.
Zhang Y, Rohde C, Reinhardt R, Voelcker-Rehage C, Jeltsch A. Non-imprinted allele-specific DNA methylation on human autosomes. Genome Biol. 2009;10(12):R138. PMID: 19958531
Rohde C, Zhang Y, Stamerjohanns H, Hecher K, Reinhardt R, Jeltsch A. New clustering module in BDPC bisulfite sequencing data presentation and compilation web application for DNA methylation analyses. Biotechniques. 2009;47(3):781-3. PMID: 19852764
Chahar S, Elsawy H, Ragozin S, Jeltsch A. Changing the DNA recognition specificity of the EcoDam DNA-(adenine-N6)-methyltransferase by directed evolution. J Mol Biol. 2010;395(1):79-88. PMID: 19766657
Dhayalan A, Dimitrova E, Rathert P, Jeltsch A.A continuous protein methyltransferase (G9a) assay for enzyme activity measurement and inhibitor screening. J Biomol Screen. 2009;14(9):1129-33. PMID: 19734436
Elsawy H, Podobinschi S, Chahar S, Jeltsch A. Transition from EcoDam to T4Dam DNA recognition mechanism without loss of activity and specificity. Chembiochem. 2009;10(15):2488-93. PMID: 19725089
Schäfer A, Wolf DH. Sec61p is part of the endoplasmic reticulum-associated degradation machinery. EMBO J. 2009;28(19):2874-84. PMID: 19696741
Pingoud V, Wende W, Friedhoff P, Reuter M, Alves J, Jeltsch A, Mones L, Fuxreiter M, Pingoud A. On the divalent metal ion dependence of DNA cleavage by restriction endonucleases of the EcoRI family. J Mol Biol. 2009;393(1):140-60. PMID: 19682999
Gao T, Collins RE, Horton JR, Zhang X, Zhang R, Dhayalan A, Tamas R, Jeltsch A, Cheng X. The ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine binding. Proteins. 2009;76(3):772-7. PMID: 19434754
Rathert P, Dhayalan A, Ma H, Jeltsch A. Specificity of protein lysine methyltransferases and methods for detection of lysine methylation of non-histone proteins. Mol Biosyst. 2008;4(12):1186-90. Review. PMID: 19396382
Alberts SM, Sonntag C, Schäfer A, Wolf DH. Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum. J Biol Chem. 2009;284(24):16082-9. PMID: 19359248
Zhang Y, Rohde C, Tierling S, Jurkowski TP, Bock C, Santacruz D, Ragozin S, Reinhardt R, Groth M, Walter J, Jeltsch A. DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution. PLoS Genet. 2009;5(3):e1000438. PMID: 19325872
Maltseva DV, Baykov AA, Jeltsch A, Gromova ES.Impact of 7,8-dihydro-8-oxoguanine on methylation of the CpG site by Dnmt3a.Biochemistry. 2009;48(6):1361-8. PMID: 19161295
Jurkowski TP, Jeltsch A. Mechanism and Evolution of DNA Recognition by DNA-(adenine N6)-Methyltransferases from the EcoDam Family. In: Grosjean H, editor. DNA and RNA Modification Enzymes: Comparative Structure, Mechanism, Functions, Cellular Interactions and Evolution Austin (Texas): Landes Bioscience; 2009.
Zhang Y, Rohde C, Tierling S, Stamerjohanns H, Reinhardt R, Walter J, Jeltsch A.DNA methylation analysis by bisulfite conversion, cloning, and sequencing of individual clones.Methods Mol Biol. 2009;507:177-87. PMID: 18987815
Eisele F, Wolf DH. Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1. FEBS Lett. 2008;582(30):4143-6. PMID: 19041308
Jurkowska RZ, Anspach N, Urbanke C, Jia D, Reinhardt R, Nellen W, Cheng X, Jeltsch A. Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L. Nucleic Acids Res. 2008;36(21):6656-63. PMID: 18945701
Jeltsch A. Reading and writing DNA methylation. Nat Struct Mol Biol. 2008;15(10):1003-4. PMID: 18836494
Jeltsch A, Rathert P. Putting the pieces together: histone H2B ubiquitylation directly stimulates histone H3K79 methylation. Chembiochem. 2008;9(14):2193-5. PMID: 18712750
Jurkowski TP, Meusburger M, Phalke S, Helm M, Nellen W, Reuter G, Jeltsch A. Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. RNA. 2008;14(8):1663-70. PMID: 18567810
Kohlmann S, Schäfer A, Wolf DH. Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation. J Biol Chem. 2008;283(24):16374-83. PMID: 18436532
Rathert P, Dhayalan A, Murakami M, Zhang X, Tamas R, Jurkowska R, Komatsu Y, Shinkai Y, Cheng X, Jeltsch A.Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol. 2008;4(6):344-6. PMID: 18438403
van der Gun BT, Wasserkort R, Monami A, Jeltsch A, Raskó T, Slaska-Kiss K, Cortese R, Rots MG, de Leij LF, Ruiters MH, Kiss A, Weinhold E, McLaughlin PM. Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation. Int J Cancer. 2008;123(2):484-9. PMID: 18398839
Santt O, Pfirrmann T, Braun B, Juretschke J, Kimmig P, Scheel H, Hofmann K, Thumm M, Wolf DH. The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism. Mol Biol Cell. 2008;19(8):3323-33. PMID: 18508925
Métivier R, Gallais R, Tiffoche C, Le Péron C, Jurkowska RZ, Carmouche RP, Ibberson D, Barath P, Demay F, Reid G, Benes V, Jeltsch A, Gannon F, Salbert G. Cyclical DNA methylation of a transcriptionally active promoter. Nature. 2008;452(7183):45-50. PMID: 18322525
Rohde C, Zhang Y, Jurkowski TP, Stamerjohanns H, Reinhardt R, Jeltsch A. Bisulfite sequencing Data Presentation and Compilation (BDPC) web server--a useful tool for DNA methylation analysis. Nucleic Acids Res. 2008;36(5):e34. PMID: 18296484
Liebert K, Jeltsch A. Detection and quantitation of the activity of DNA methyltransferases using a biotin/avidin microplate assay. Methods Mol Biol. 2008;418:149-56. PMID: 18287657
Rathert P, Zhang X, Freund C, Cheng X, Jeltsch A. Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferase using peptide arrays. Chem Biol. 2008;15(1):5-11. PMID: 18215768
Dhayalan A, Jurkowski TP, Laser H, Reinhardt R, Jia D, Cheng X, Jeltsch A. Mapping of protein-protein interaction sites by the 'absence of interference' approach. J Mol Biol. 2008;376(4):1091-9. PMID: 18191145
Raasi S, Wolf DH. Ubiquitin receptors and ERAD: a network of pathways to the proteasome. Semin Cell Dev Biol. 2007 Dec;18(6):780-91. Review. PMID: 17942349
Rathert P, Cheng X, Jeltsch A. Continuous enzymatic assay for histone lysine methyltransferases. Biotechniques. 2007 Nov;43(5):6026. PMID: 18072589
Jurkowski TP, Anspach N, Kulishova L, Nellen W, Jeltsch A. The M.EcoRV DNA-(adenine N6)-methyltransferase uses DNA bending for recognition of an expanded EcoDam recognition site. J Biol Chem. 2007;282(51):36942-52. PMID: 17977824
Goyal R, Rathert P, Laser H, Gowher H, Jeltsch A. Phosphorylation of serine-515 activates the Mammalian maintenance methyltransferase Dnmt1. Epigenetics. 2007;2(3):155-60. PMID: 17965600
Jia D, Jurkowska RZ, Zhang X, Jeltsch A, Cheng X. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. Nature. 2007;449(7159):248-51. PMID: 17713477
Gallais R, Demay F, Barath P, Finot L, Jurkowska R, Le Guével R, Gay F, Jeltsch A, Métivier R, Salbert G. Deoxyribonucleic acid methyl transferases 3a and 3b associate with the nuclear orphan receptor COUP-TFI during gene activation. Mol Endocrinol. 2007;21(9):2085-98. PMID: 17579209
Liebert K, Horton JR, Chahar S, Orwick M, Cheng X, Jeltsch A. Two alternative conformations of S-adenosyl-L-homocysteine bound to Escherichia coli DNA adenine methyltransferase and the implication of conformational changes in regulating the catalytic cycle. J Biol Chem. 2007;282(31):22848-55. PMID: 17545164
Jeltsch A, Jurkowska RZ, Jurkowski TP, Liebert K, Rathert P, Schlickenrieder M. Application of DNA methyltransferases in targeted DNA methylation. Appl Microbiol Biotechnol. 2007;75(6):1233-40. Review. PMID: 17431611
Rathert P, Raskó T, Roth M, Slaska-Kiss K, Pingoud A, Kiss A, Jeltsch A. Reversible inactivation of the CG specific SssI DNA (cytosine-C5)-methyltransferase with a photocleavable protecting group. Chembiochem. 2007;8(2):202-7. PMID: 17195251
Park SH, Bolender N, Eisele F, Kostova Z, Takeuchi J, Coffino P, Wolf DH. The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system. Mol Biol Cell. 2007;18(1):153-65. PMID: 17065559
Li F, Papworth M, Minczuk M, Rohde C, Zhang Y, Ragozin S, Jeltsch A. Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. Nucleic Acids Res. 2007;35(1):100-12. PMID: 17151075
Persönliche Publikationslisten
- Prof. Jeltsch - Web of Science
Web of Science Liste mit Links, Zitationen und H-Index - Prof. Jeltsch - ORCID
0000-0001-6113-9290 - Prof. Jeltsch - NCBI Publikationsliste
NCBI Publikationsliste mit Links - Prof. Jeltsch - Google Scholar
Google Scholar Liste mit Links, Zitationen und H-Index - PD Dr. Rathert
Vollständige Liste und ausgewählte Publikationen - PD Dr. Rathert - Google Scholar
Google Scholar Liste mit Links, Zitationen und H-Index - Dr. Bashtrykov - Google Scholar
Google Scholar Liste mit Links, Zitationen und H-Index - Dr. Weirich - Google Scholar
Google Scholar Liste mit Links, Zitationen und H-Index
Bücher
- Jeltsch & Rots (editors): Epigenome Editing - Methods and Protocols (2nd edition). Methods in Molecular Biology 2842, Springer-Nature, 2024
- Jeltsch & Jurkowska (editors): DNA Methyltransferases - Role and Function. 2nd heavily revised edition. Springer-Nature, 2022
- Jeltsch & Dhayalan (editors): Structure, Activity, and Function of Protein Methyltransferases. MDPI, Basel, 2022
- Jeltsch & Gowher (editors): Role of DNA Methyltransferases in the Epigenome. MDPI, Basel, 2020
- Jeltsch & Rots (editors): Epigenome Editing - Methods and Protocols. Methods in Molecular Biology 1767, Springer-Nature, 2018
- Jeltsch & Jurkowska (editors): DNA Methyltransferases - Role and Function. Springer-Nature, 2017
Meldungen zu Publikationen
Kontakt
Albert Jeltsch
Prof. Dr.Abteilungsleiter Biochemie und Geschäftsführender Institutsleiter IBTB