Publikationen

Veröffentlichungen der Arbeitsgruppe von Prof. Dr. Jens Brockmeyer

  1. Wangorsch, A., Kulkarni, A., Jamin, A., Spiric, J., Bräcker, J., Brockmeyer, J., Mahler, V., Blanca-López, N., Ferrer, M., Blanca, M., Torres, M., Gomez, P., Bartra, J., García-Moral, A., Goikoetxea, M. J., Vieths, S., Toda, M., Zoccatelli, G., & Scheurer, S. (2020). Identification and Characterization of IgE-Reactive Proteins and a New Allergen (Cic~a~1.01) from Chickpea (Cicer arietinum). Molecular Nutrition & Food Research, 2000560. https://doi.org/10.1002/mnfr.202000560
  2. Gutiérrez, Y., Fresch, M., Ott, D., Brockmeyer, J., & Scherber, C. (2020). Diet composition and social environment determine food consumption, phenotype and fecundity in an omnivorous insect. Royal Society Open Science, 7(4), 200100. https://doi.org/10.1098/rsos.200100
  3. Stoyke, M., Becker, R., Brockmeyer, J., Jira, W., Popping, B., Uhlig, S., & Wittke, S. (2019). German Government Official Methods Board Points the Way Forward: Launch of a New Working Group for Mass Spectrometry for Protein Analysis to Detect Food Fraud and Food Allergens. Journal of AOAC International, 102(5), 1280--1285. https://doi.org/10.1093/jaoac/102.5.1280
  4. Fiorino, G. M., Fresch, M., Brümmer, I., Losito, I., Arlorio, M., Brockmeyer, J., & Monaci, L. (2019). Mass Spectrometry-Based Untargeted Proteomics for the Assessment of Food Authenticity: The Case of Farmed Versus Wild-Type Salmon. Journal of AOAC International, 102(5), 1339–1345. https://doi.org/10.1093/jaoac/102.5.1339
  5. Korte, R., Oberleitner, D., & Brockmeyer, J. (2019). Determination of food allergens by LC-MS: Impacts of sample preparation, food matrix, and thermal processing on peptide detectability and quantification. Journal of Proteomics, 196, 131--140. https://doi.org/10.1016/j.jprot.2018.11.002
  6. Becker, R., Wittke, S., Brockmeyer, J., Schwägele, F., Jira, W., Uhlig, S., Pöpping, B., Szabo, K., & Stoyke, M. (2018). Das erste Treffen der § 64 LFGB Arbeitsgruppe „Massenspektrometrische Proteinanalytik``. Journal of Consumer Protection and Food Safety, 13(3), 329--333. https://doi.org/10.1007/s00003-018-1170-0
  7. Bräcker, J., & Brockmeyer, J. (2018). Characterization and Detection of Food Allergens Using High-Resolution Mass Spectrometry: Current Status and Future Perspective. Journal of Agricultural and Food Chemistry, 66(34), 8935–8940. https://doi.org/10.1021/acs.jafc.8b02265
  8. Hummel, M., Wigger, T., & Brockmeyer, J. (2018). Characterization of Structural Variability of the Allergenic 2S Albumin Ses i 1 Using Combinatorial Proteomics. Journal of Analysis and Testing, 2(2), 158–167. https://doi.org/10.1007/s41664-018-0064-6
  9. Brockmeyer, J. (2018). Novel Approaches for the MS-Based Detection of Food Allergens: High Resolution, MS3, and Beyond. Journal of AOAC International, 101(1), 124–131. https://doi.org/10.5740/jaoacint.17-0402
  10. Brümmer, I., Klußmann, A., & Brockmeyer, J. (2018). Authentizität von Lebensmitteln - “Echter” Thunfisch Isobares Labeling als Methode zur Identifizierung von Markerpeptiden zum Authentizitätsnachweis. Deutsche Lebensmittel-Rundschau, 114(4), 156–163.
  11. Korte, R., & Brockmeyer, J. (2017). Novel mass spectrometry approaches in food proteomics. TrAC Trends in Analytical Chemistry, 96, 99–106. https://doi.org/10.1016/j.trac.2017.07.010
  12. Korte, R., Bräcker, J., & Brockmeyer, J. (2017). Back cover: Gastrointestinal digestion of hazelnut allergens on molecular level: Elucidation of degradation kinetics and resistant immunoactive peptides using mass spectrometry. Molecular Nutrition and Food Research, 61(10), 1770104. https://doi.org/10.1002/mnfr.201770104
  13. Korte, R., Bräcker, J., & Brockmeyer, J. (2017). Gastrointestinal digestion of hazelnut allergens on molecular level: Elucidation of degradation kinetics and resistant immunoactive peptides using mass spectrometry. Molecular Nutrition & Food Research, 61(10), 1700130. https://doi.org/10.1002/mnfr.201700130
  14. Korte, R., Happe, J., Brümmer, I., & Brockmeyer, J. (2017). Structural Characterization of the Allergenic 2S Albumin Cor a 14: Comparing Proteoform Patterns across Hazelnut Cultivars. Journal of Proteome Research, 16(2), 988–998. https://doi.org/10.1021/acs.jproteome.6b00924
  15. Korte, R., & Brockmeyer, J. (2016). MRM3-based LC-MS multi-method for the detection and quantification of nut allergens. Analytical and Bioanalytical Chemistry, 408(27), 7845–7855. https://doi.org/10.1007/s00216-016-9888-y
  16. Korte, R., Monneuse, J.-M., Gemrot, E., Metton, I., Humpf, H.-U., & Brockmeyer, J. (2016). New High-Performance Liquid Chromatography Coupled Mass Spectrometry Method for the Detection of Lobster and Shrimp Allergens in Food Samples via Multiple Reaction Monitoring and Multiple Reaction Monitoring Cubed. Journal of Agricultural and Food Chemistry, 64(31), 6219–6227. https://doi.org/10.1021/acs.jafc.6b02620
  17. Korte, R., Lepski, S., & Brockmeyer, J. (2016). Comprehensive peptide marker identification for the detection of multiple nut allergens using a non-targeted LC--HRMS multi-method. Analytical and Bioanalytical Chemistry, 408(12), 3059--3069. https://doi.org/10.1007/s00216-016-9384-4
  18. Hummel, M., Wigger, T., Höper, T., Westkamp, I., & Brockmeyer, J. (2015). Simple, Rapid, and Selective Isolation of 2S Albumins from Allergenic Seeds and Nuts. Journal of Agricultural and Food Chemistry, 63(26), 6035--6040. https://doi.org/10.1021/acs.jafc.5b01634
  19. Gossmann, R., Fahrländer, E., Hummel, M., Mulac, D., Brockmeyer, J., & Langer, K. (2015). Comparative examination of adsorption of serum proteins on HSA- and PLGA-based nanoparticles using SDS–PAGE and LC–MS. European Journal of Pharmaceutics and Biopharmaceutics, 93, 80--87. https://doi.org/10.1016/j.ejpb.2015.03.021
  20. Brockmeyer, J. (2015). Trendbericht Lebensmittelchemie 2014. Nachrichten Aus Der Chemie, 63(3), 348–353.
  21. Hummel, M., Wigger, T., & Brockmeyer, J. (2015). Characterization of Mustard 2S Albumin Allergens by Bottom-up, Middle-down, and Top-down Proteomics: A Consensus Set of Isoforms of Sin a 1. Journal of Proteome Research, 14(3), 1547--1556. https://doi.org/10.1021/pr5012262
  22. Weiss, A., Joerss, H., & Brockmeyer, J. (2014). Structural and Functional Characterization of Cleavage and Inactivation of Human Serine Protease Inhibitors by the Bacterial SPATE Protease EspPα from Enterohemorrhagic E. coli. PLOS ONE, 9(10), 1–12. https://doi.org/10.1371/journal.pone.0111363
  23. von Bargen, C., Humpf, H.-U., & Brockmeyer, J. (2014). Pferd oder Rind? Nachrichten Aus Der Chemie, 62(9), 883–885. https://doi.org/10.1002/nadc.201490297
  24. Weiss, A., Kortemeier, D., & Brockmeyer, J. (2014). Biochemical Characterization of the SPATE Members EspPα and EspI. Toxins, 6(9), 2719--2731. https://doi.org/10.3390/toxins6092719
  25. von Bargen, C., Brockmeyer, J., & Humpf, H.-U. (2014). Meat Authentication: A New HPLC–MS/MS Based Method for the Fast and Sensitive Detection of Horse and Pork in Highly Processed Food. Journal of Agricultural and Food Chemistry, 62(39), 9428--9435. https://doi.org/10.1021/jf503468t
  26. Hummel, M., Wigger, T., & Brockmeyer, J. (2014). Identification and characterization of allergens in spices by mass spectrometry. Clinical and Translational Allergy, 4(2), P1. https://doi.org/10.1186/2045-7022-4-S2-P1
  27. Poolpol, K., Orth-Höller, D., Speth, C., Zipfel, P. F., Skerka, C., de Córdoba, S. R., Brockmeyer, J., Bielaszewska, M., & Würzner, R. (2014). Interaction of Shiga toxin 2 with complement regulators of the factor H protein family. Molecular Immunology, 58(1), 77--84. https://doi.org/10.1016/j.molimm.2013.11.009
  28. von Bargen, C., Dojahn, J., Waidelich, D., Humpf, H.-U., & Brockmeyer, J. (2013). New Sensitive High-Performance Liquid Chromatography–Tandem Mass Spectrometry Method for the Detection of Horse and Pork in Halal Beef. Journal of Agricultural and Food Chemistry, 61(49), 11986--11994. https://doi.org/10.1021/jf404121b
  29. Ehrlenbach, S., Rosales, A., Posch, W., Wilflingseder, D., Hermann, M., Brockmeyer, J., Karch, H., Satchell, S. C., Würzner, R., & Orth-Höller, D. (2013). Shiga Toxin 2 Reduces Complement Inhibitor CD59 Expression on Human Renal Tubular Epithelial and Glomerular Endothelial Cells. Infection and Immunity, 81(8), 2678–2685. https://doi.org/10.1128/IAI.01079-12
  30. Hummel, M., & Brockmeyer, J. (2013). Identification of major allergens in spices by mass spectrometry. Clinical and Translational Allergy, 3(3), P55. https://doi.org/10.1186/2045-7022-3-S3-P55
  31. Lepski, S., Gerwin, J., & Brockmeyer, J. (2013). Detection of nut allergens by mass spectrometry and structure analysis after food processing. Clinical and Translational Allergy, 3(3), 56. https://doi.org/10.1186/2045-7022-3-S3-P56
  32. Lepski, S., & Brockmeyer, J. (2013). Impact of dietary factors and food processing on food allergy. Molecular Nutrition and Food Research, 57(1), 145–152. https://doi.org/10.1002/mnfr.201200472
  33. Weiss, A., & Brockmeyer, J. (2012). Prevalence, Biogenesis, and Functionality of the Serine Protease Autotransporter EspP. Toxins, 5(1), 25--48. https://doi.org/10.3390/toxins5010025
  34. Brockmeyer, J., Aldick, T., Soltwisch, J., Zhang, W., Tarr, P. I., Weiss, A., Dreisewerd, K., Müthing, J., Bielaszewska, M., & Karch, H. (2011). Enterohaemorrhagic Escherichia coli haemolysin is cleaved and inactivated by serine protease EspPα. Environmental Microbiology, 13(5), 1327–1341. https://doi.org/10.1111/j.1462-2920.2011.02431.x
  35. Orth, D., Ehrlenbach, S., Brockmeyer, J., Khan, A. B., Huber, G., Karch, H., Sarg, B., Lindner, H., & Würzner, R. (2010). EspP, a Serine Protease of Enterohemorrhagic Escherichia coli, Impairs Complement Activation by Cleaving Complement Factors C3/C3b and C5. Infection and Immunity, 78(10), 4294–4391. https://doi.org/10.1128/IAI.00488-10
  36. Brockmeyer, J. (2010). Bioactive Compounds in Milk and Dairy Products Young W. Park (Ed.) Wiley‐Blackwell, 2009, pp. 440 ISBN‐13: 978‐0‐8138‐1982‐2. Molecular Nutrition and Food Research, 54(4), 576. https://doi.org/10.1002/mnfr.201090012
  37. Brockmeyer, J. (2010). Management of Food Allergens Jaqueline Coutts and Richard Fielder (Eds.) Wiley‐Blackwell, 2009, pp. 272 ISBN‐13: 978‐1‐4051‐6758‐1. Molecular Nutrition and Food Research, 54(3), 440. https://doi.org/10.1002/mnfr.201090008
  38. Brockmeyer, J., Spelten, S., Kuczius, T., Bielaszewska, M., & Karch, H. (2009). Structure and Function Relationship of the Autotransport and Proteolytic Activity of EspP from Shiga Toxin-Producing Escherichia coli. PLOS ONE, 4(7), 1–11. https://doi.org/10.1371/journal.pone.0006100
  39. Orth, D., Khan, A. B., Naim, A., Grif, K., Brockmeyer, J., Karch, H., Joannidis, M., Clark, S. J., Day, A. J., Fidanzi, S., Stoiber, H., Dierich, M. P., Zimmerhackl, L. B., & Würzner, R. (2009). Shiga Toxin Activates Complement and Binds Factor H: Evidence for an Active Role of Complement in Hemolytic Uremic Syndrome. The Journal of Immunology, 182(10), 6394–6400. https://doi.org/10.4049/jimmunol.0900151
  40. Bielaszewska, M., Stoewe, F., Fruth, A., Zhang, W., Prager, R., Brockmeyer, J., Mellmann, A., Karch, H., & Friedrich, A. W. (2009). Shiga Toxin, Cytolethal Distending Toxin, and Hemolysin Repertoires in Clinical Escherichia coli O91 Isolates. Journal of Clinical Microbiology, 47(7), 2061. https://doi.org/10.1128/JCM.00201-09
  41. Werth, S., Brockmeyer, J., Luegering, A., Karch, H., Domschke, W. W., Bruewer, M., & Heidemann, J. (2008). W1191 Effects of Ehec-Derived Autotransporter Serine Protease Espp On Human Endothelial Cells. Gastroenterology, 134(4), A--652. https://doi.org/10.1016/s0016-5085(08)63043-7
  42. Brockmeyer, J., Bielaszewska, M., Fruth, A., Bonn, M. L., Mellmann, A., Humpf, H.-U., & Karch, H. (2007). Subtypes of the Plasmid-Encoded Serine Protease EspP in Shiga Toxin-Producing Escherichia coli: Distribution, Secretion, and Proteolytic Activity. Applied and Environmental Microbiology, 73(20), 6351. https://doi.org/10.1128/AEM.00920-07
  43. Aldick, T., Bielaszewska, M., Zhang, W., Brockmeyer, J., Schmidt, H., Friedrich, A. W., Kim, K. S., Schmidt, M. A., & Karch, H. (2007). Hemolysin from Shiga toxin-negative Escherichia coli O26 strains injures microvascular endothelium. Microbes and Infection, 9(3), 282--290. https://doi.org/10.1016/j.micinf.2006.12.001
  44. Werth, S., Brockmeyer, J., Karch, H., Koch, S., Kucharzik, T., Brüwer, M., Maaser, C., & Heidemann, J. (2007). Proinflammatorische Effekte des EHEC-assoziierten Exotoxins EspP in humanen intestinalen mikrovaskulären Endothelzellen (HIMEC). Zeitschrift Für Gastroenterologie, 45(08), 238. https://doi.org/10.1055/s-2007-988384
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