Dieses Bild zeigt Bernhard Hauer

Bernhard Hauer

Herr Prof. Dr.

Head of the Technical Biochemistry Department
Institute of Biochemistry and Technical Biochemistry
Technical Biochemistry

Kontakt

+49 711 685 63193
+49 711 685 63196

Allmandring 31
70569 Stuttgart
Deutschland
Raum: 0.303

  1. 2023

    1. Schell K, Li H, Lauterbach L, Taizoumbe KA, Dickschat JS, Hauer B. Alternative Active Site Confinement in Squalene–Hopene Cyclase Enforces Substrate Preorganization for Cyclization. ACS Catal [Internet]. April 2023;13(7):5073--5083. Verfügbar unter: https://doi.org/10.1021/acscatal.2c05949
    2. Aberle B, Kowalczyk D, Massini S, Egler-Kemmerer AN, Gergel S, Hammer SC, u. a. Methylation of Unactivated Alkenes with Engineered Methyltransferases To Generate Non-natural Terpenoids. Angewandte Chemie [Internet]. März 2023;62(26). Verfügbar unter: https://doi.org/10.1002/anie.202301601
    3. Schneider A, Ruppert J, Lystbæk TB, Bastian S, Hauer B. Expanding the Cation Cage: Squalene-Hopene Cyclase-Mediated Enantioselective Semipinacol Rearrangement. ACS Catal [Internet]. Februar 2023;13(3):1946--1951. Verfügbar unter: https://doi.org/10.1021/acscatal.2c03835
    4. Schelle JT, Lepoittevin W, Hauer B. Enhanced Semi-Preparative Biotransformation of Cumene Dioxygenase: From Analytical Scale to Product Isolation . Chemie Ingenieur Technik [Internet]. 2023;95(4):607–11. Verfügbar unter: https://onlinelibrary.wiley.com/doi/abs/10.1002/cite.202200162
    5. Schneider A, Curado C, Lystbaek TB, Osuna S, Hauer B. Harnessing the Structure and Dynamics of the Squalene-Hopene Cyclase for (−)-Ambroxide Production**. Angewandte Chemie International Edition [Internet]. 2023;62(22):e202301607. Verfügbar unter: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202301607
  2. 2022

    1. Benítez-Mateos AI, Schneider A, Hegarty E, Hauer B, Paradisi F. Spheroplasts preparation boosts the catalytic potential of a squalene-hopene cyclase. Nature Communications [Internet]. 2022;13(1):6269--. Verfügbar unter: https://doi.org/10.1038/s41467-022-34030-0
    2. Rapp L, Marques S, Nebel B, Damborsky J, Hauer B. Engineering CYP153A M.aq to Oxyfunctionalize its Inhibitor Dodecylamine Using a LC/MS Based Rapid Flow Analysis Screening. ChemCatChem. 2022;
  3. 2021

    1. Henche S, Nestl B, Hauer B. Enzymatic Friedel-Crafts Alkylation Using Squalene-Hopene Cyclases. ChemCatChem. 2021;
    2. Heinemann P, Armbruster D, Hauer B. Active-site loop variations adjust activity and selectivity of the cumene dioxygenase. Nature Communications. 2021;12:1095.
    3. Wissner J, Schelle J, Escobedo W, Vogel A, Hauer B. Semi‐Rational Engineering of Toluene Dioxygenase from Pseudomonas putida F1 towards Oxyfunctionalization of Bicyclic Aromatics. Advanced Synthesis & Catalysis. 2021;363:1–11.
    4. Bengel L, Aberle B, Egler-Kemmerer AN, Kienzle S, Hauer B, Hammer S. Engineered enzymes enable selective N-alkylation of pyrazoles with simple haloalkanes. Angewandte Chemie International Edition [Internet]. 2021;60:2–9. Verfügbar unter: https://doi.org/10.1002/anie.202014239
    5. Schneider A, Jegl P, Hauer B. Stereoselective Directed Cationic Cascades Enabled by Molecular Anchoring in Terpene Cyclases. Angewandte Chemie International Edition. 2021;60:2–8.
    6. Hunold A, Escobedo W, Potoudis E, Resende D, Farr T, Syrén P, u. a. Assembly of a Rieske non-heme iron oxygenase multicomponent system from Phenylobacterium immobile E DSM 1986 enables pyrazon cis-dihydroxylation in E. coli. Applied Microbiology and Biotechnology. 2021;105:2003–20015.
    7. Escobedo W, Wissner J, Hauer B. A real-time 31 P-NMR-based approach for the assessment of glycerol kinase catalyzed monophosphorylations. MethodsX. 2021;8.
    8. Farr T, Wissner J, Hauer B. A simple and efficient method for lyophilization of recombinant E. coli JM109 (DE3) whole-cells harboring active Rieske non-heme iron dioxygenases. MethodsX. 2021;8.
    9. Escobedo W, Hammer S, Wissner J, Hauer B. Fast and easy synthesis of the non-commercially available standard isobutyl monophosphate (ammonium salt). MethodsX. 2021;8:101455.
    10. Wissner J, Escobedo W, Vogel A, Hauer B. An engineered toluene dioxygenase for a single step biocatalytical production of (-)-(1S,2R)-cis-1,2-dihydro-1,2-naphthalenediol. Journal of Biotechnology. 2021;326:37–9.
    11. Rapp L, Marques S, Zukic E, Rowlinson B, Sharma M, Grogan G, u. a. Substrate Anchoring and Flexibility Reduction in CYP153AM.aq Leads to Highly Improved Efficiency toward Octanoic Acid. ACS Catalysis. 2021;11:3182–9.
  4. 2020

    1. Klenk J, Ertl J, Rapp L, Fischer MP, Hauer B. Expression and characterization of the benzoic acid hydroxylase CYP199A25 from Arthrobacter sp. Molecular Catalysis. 2020;484.
    2. Hauer B. Embracing Nature’s Catalysts: A Viewpoint on the Future of Biocatalysis. ACS Catalysis. 2020;10:8418–27.
    3. Wissner J, Ludwig J, Escobedo W, Hauer B. Strategy for identification of cis -dihydrodiendiol-degrading dehydrogenases in E. coli BW25113. MethodsX. 2020;7:101143.
    4. Wissner J, Ludwig L, Escobedo W, Hauer B. An enhanced toluene dioxygenase platform for the production of cis-1,2-dihydrocatechol in Escherichia coli BW25113 lacking glycerol dehydrogenase activity. Journal of Biotechnology. 2020;
    5. Heinemann P, Rapp L, Hauer B. Loops und Tunnel: unterschätzte Elemente in Enzymen. BIOspektrum. 2020;26.4:434–6.
    6. Wissner J, Escobedo W, Heinemann P, Hunold A, Hauer B. Methods for the detection and analysis of dioxygenase catalyzed dihydroxylation in mutant derived libraries. Methods in Enzymology. 2020;1–31.
  5. 2019

    1. Bornscheuer U, Hauer B, Jaeger K, Schwaneberg U. Directed Evolution Empowered Redesign of Natural Proteins for the Sustainable Production of Chemicals and Pharmaceuticals. Angewandte Chemie International Edition. 2019;58:36–40.
    2. Klaus T, Seifert A, Häbe T, Nestl B, Hauer B. An Enzyme Cascade Synthesis of Vanillin. Catalysts. 2019;9.
    3. Demming R, Hammer S, Nestl B, Gergel S, Fademrecht S, Pleiss J, u. a. Asymmetric Enzymatic Hydration of Unactivated, Aliphatic Alkenes. Angew Chem Int Ed Engl. 2019;58:173–7.
    4. Klenk J, Kontny L, Escobedo W, Nebel B, Hauer B. Oxyfunctionalization of nonsteroidal anti‐inflammatory drugs by filamentous‐fungi. Journal of Applied Microbiology. 2019;127:724–38.
    5. Hinner L, Wissner J, Hauer B, Nebel B. Efficient cellulose dissolution in a tertiary EHEMIM-EMIMOAc-water system. Journal of Molecular Liquids. 2019;281:236–42.
    6. Allgaier M, Halder J, Kittelberger J, Hauer B, Nebel B. A simple and robust LC-ESI single quadrupole MS-based method to analyze neonicotinoids in honey bee extracts. MethodsX. 2019;6:2484–91.
    7. Li W, Jayakody L, Franden M, Wehrmann M, Daun T, Hauer B, u. a. Laboratory evolution reveals the metabolic and regulatory basis of ethylene glycol metabolism by Pseudomonas putida KT2440. Environmental Microbiology. 2019;21:3669–82.
  6. 2018

    1. Kress N, Halder J, Rapp L, Hauer B. Unlocked potential of dynamic elements in protein structures: channels and loops. Curr Opin Chem Biol. 2018;47:109–16.
    2. Facey S, Nebel B, Kontny L, Allgaier M, Hauer B. Rapid and complete degradation of diclofenac by native soil microorganisms. Environmental Technology & Innovation. 2018;10:55–61.
    3. Halder J, Nestl B, Hauer B. Semi-Rational Engineering of the Naphthalene Dioxygenase from Pseudomonas sp. NCIB 9816-4 towards Selective Asymmetric Dihydroxylation. ChemCatChem. 2018;10:178–82.
    4. Demming R, Fischer M, Schmid J, Hauer B. (De)hydratases-recent developments and future perspectives. Curr Opin Chem Biol. 2018;43:43–50.
    5. Klenk J, Dubiel P, Sharma M, Grogan G, Hauer B. Characterization and structure‐guided engineering of the novel versatile terpene monooxygenase CYP109Q5 from Chondromyces apiculatus DSM436. Microbial Biotechnology. 2018;377–91.
    6. Fernandes A, Halder J, Nestl B, Hauer B, Gernaey K, Krühne U. Biocatalyst Screening with a Twist: Application of Oxygen Sensors Integrated in Microchannels for Screening Whole Cell Biocatalyst Variants. Bioengineering (Basel). 2018;5(2):E30.
  7. 2017

    1. Klenk J, Nebel B, Porter J, Kulig J, Hussain S, Richter S, u. a. The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac. Biotechnol J. 2017;12:1600520.
    2. Kress N, Rapp J, Hauer B. Enantioselective Reduction of Citral Isomers in NCR Ene Reductase: Analysis of an Active-Site Mutant Library. ChemBioChem. 2017;18:717–20.
    3. Nestl B, Geinitz C, Popa S, Rizek S, Haselbeck R, Fischer M, u. a. Structural and functional insights into asymmetric enzymatic dehydration of alkenols. Nat Chem Biol. 2017;13:275–81.
    4. Demming R, Otte K, Nestl B, Hauer B. Optimized Reaction Conditions Enable the Hydration of Non-natural Substrates by the Oleate Hydratase from Elizabethkingia meningoseptica. ChemCatChem. 2017;9:758–66.
    5. Schmid J, Steiner L, Fademrecht S, Pleiss J, Otte K, Hauer B. Biocatalytic study of novel oleate hydratases. J Mol Catal B: Enzym. 2017;133:S243–9.
    6. Kühnel L, Nestl B, Hauer B. Enzymatic Addition of Alcohols to Terpenes by Squalene Hopene Cyclase Variants. ChemBioChem. 2017;18:2222–5.
    7. Bastian S, Hammer S, Kress N, Nestl B, Hauer B. Enabling New Selectivities in the Cyclization of Citronellal by Squalene Hopene Cyclase Variants. ChemCatChem. 2017;9:4364–8.
    8. Darimont D, Weissenborn M, Nebel B, Hauer B. Modulating proposed electron transfer pathways in P450BM3 led to improved activity and coupling efficiency. Bioelectrochemistry. 2017;119:119–23.
    9. Otte K, Maurer E, Kirtz M, Grabs D, Althoff E, Bartsch S, u. a. Synthesis of sebacic acid using a de novo designed retro-aldolase as key catalyst. ChemCatChem. 2017;9:1378–82.
  8. 2016

    1. Notonier S, Gricman L, Pleiss J, Hauer B. Semi-rational protein engineering of CYP153A M.aq.-CPR BM3 for efficient terminal hydroxylation of short to long chain fatty acids. ChemBioChem. 2016;17:1550–7.
    2. Wetzl D, Bolsinger J, Nestl B, Hauer B. α-Hydroxylation of Carboxylic Acids Catalyzed by Taurine Dioxygenase. ChemCatChem. 2016;8:1361–6.
    3. Hoffmann S, Weissenborn M, Gricman L, Notonier S, Pleiss J, Hauer B. The Impact of Linker Length on P450 Fusion Constructs: Activity, Stability and Coupling. ChemCatChem. 2016;8:1591–7.
    4. Moghimian P, Kilper S, Srot V, Rothenstein D, Facey SJ, Hauer B, u. a. Phage-assisted assembly of organic–inorganic hybrid bilayers. International Journal of Materials Research. 2016;
    5. Syren P, Henche S, Eichler A, Nestl B, Hauer B. Squalene-hopene cyclases - evolution, dynamics and catalytic scope. Curr Opin Struct Biol. 2016;41:73–82.
    6. Fademrecht S, Scheller P, Nestl B, Hauer B, Pleiss J. Identification of imine reductase-specific sequence motifs. Proteins. 2016;84:600–10.
    7. Reich S, Nestl B, Hauer B. Loop Grafted Old Yellow Enzymes in the Bienzymatic Cascade Reduction of Allylic Alcohols. ChemBioChem. 2016;17:561–5.
    8. Melcher M, Facey S, Henkes T, Subkowski T, Hauer B. Accelerated nucleation of hydroxyapatite using an engineered hydrophobin fusion protein. Biomacromolecules. 2016;
    9. Löw S, Löw I, Weissenborn M, Hauer B. Enhanced Ene-Reductase Activity through Alteration of Artificial Nicotinamide Cofactor Substituents. ChemCatChem. 2016;8:911–5.
    10. Hoffmann S, Danesh-Azari HR, Spandolf C, Weissenborn M, Grogan G, Hauer B. Structure-guided redesign of CYP153AM.aq. for the improved terminal hydroxylation of fatty acids. ChemCatChem. 2016;8:3234–9.
    11. Hammer S, Syren P, Hauer B. Substrate Pre-Folding and Water Molecule Organization Matters for Terpene Cyclase Catalyzed Conversion of Unnatural Substrates. Chemistry Select. 2016;1:3589–93.
    12. Llaudet E, Darimont D, Samba R, Matiychyn I, Stelzle M, Weissenborn M, u. a. Expanding an Efficient, Electrically Driven and CNT-Tagged P450 System into the Third Dimension: A Nanowired CNT-Containing and Enzyme-Stabilising 3 D Sol-Gel Electrode. ChemBioChem. 2016;17:1367–73.
    13. Lenz M, Scheller P, Richter S, Hauer B, Nestl B. Cultivation and purification of two stereoselective imine reductases from Streptosporangium roseum and Paenibacillus elgii. Protein Expr Purif. 2016;
  9. 2015

    1. Steudle A, Nestl B, Hauer B, Stubenrauch C. Activity of squalene-hopene cyclases in bicontinuous microemulsions. Colloids and Surfaces B: Biointerfaces. 2015;135:735–41.
    2. Hammer S, Marjanovic A, Dominicus J, Nestl B, Hauer B. Squalene Hopene Cyclases - Potency as Protonases for Stereoselective Brønsted Acid Catalysis. Nature Chemical Biology. 2015;11:121–6.
    3. Reznicek O, Facey SJ, Hauer B. Draft Genome Sequence of a Papaverine-Degrading, Gram-positive Arthrobacter sp., Isolated from Soil Near Hohenheim, Germany. Genome Announcements. 2015;3:e00422-15.
    4. Lonsdale T, Lauterbach L, Honda MS, Nestl B, Hauer B, Lenz O. H2-driven biotransformation of n-octane to Q1 1-octanol by Q2 a recombinant Pseudomonas putida strain co-synthesizing an O2-tolerant hydrogenase and a P450 monooxygenase. Chem Commun. 2015;51:16173–5.
    5. Reznicek O, Luesken F, Facey SJ, Hauer B. Draft Genome Sequence of Phenylobacterium immobile Strain E (DSM 1986), Isolated from Uncontaminated Soil in Ecuador. Genome Announcements. 2015;3:e00420-15.
    6. Lundemo M, Notonier S, Striedner G, Hauer B, Woodley J. Process limitations of a whole-cell P450 catalyzed reaction using a CYP153A-CPR fusion construct expressed in Escherichia coli. Appl Microbiol Biotechnol. 2015;100:1197–208.
    7. Scheller P, Lenz M, Hammer S, Hauer B, Nestl B. Imine Reductase-Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones. ChemCatChem. 2015;7:3239–42.
    8. Sandig B, Michalek L, Vlahovic S, Antonovici M, Hauer B, Buchmeiser M. A Monolithic Hybrid Cellulose-2.5-Acetate/Polymer Bioreactor for Biocatalysis under Continuous Liquid-Liquid Conditions Using a Supported Ionic Liquid Phase. Chemistry. 2015;21:15835–42.
    9. Löw S, Nestl B, Weissenborn M, Zepeck F, Hauer B. Process Investigations on the One-Pot Synthesis of Rifamycin S Avoiding Chlorinated Solvents. Org Process Res Dev. 2015;19:1544–7.
    10. Reznicek O, Facey SJ, de WPP, Teunissen AWRH, de BJAM, Nijland JG, u. a. Improved xylose uptake in Saccharomyces cerevisiae due to directed evolution of galactose permease Gal2 for sugar co-consumption. Journal of Applied Microbiology. 2015;119:99–111.
    11. Gally C, Nestl B, Hauer B. Engineering Rieske Non-Heme Iron Oxygenases for the Asymmetric Dihydroxylation of Alkenes. Angew Chem Int Ed. 2015;54:12952–6.
    12. Otte K, Hauer B. Enzyme engineering in the context of novel pathways and products. Curr Opin Biotechnol. 2015;35:16–22.
  10. 2014

    1. Moghimian P, Srot V, Rothenstein D, Facey SJ, Harnau L, Hauer B, u. a. Adsorption and Self-Assembly of M13 Phage into Directionally Organized Structures on C and SiO2 Films. Langmuir. 2014;30:11428–32.
    2. Reich S, Kress N, Nestl B, Hauer B. Variations in the stability of NCR ene reductase by rational enzyme loop modulation. J Struct Biol. 2014;185:228–33.
    3. Scheller P, Fademrecht S, Hofelzer S, Pleiss J, Leipold F, Turner N, u. a. Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases. ChemBioChem. 2014;15:2201–4.
    4. Syren P, Hammer S, Classen B, Hauer B. Entropy is Key to the Formation of Pentacyclic Terpenoids by Enzyme-Catalyzed Polycyclization. Angew Chem Int Ed. 2014;53:4845–9.
    5. Ploss M, Facey SJ, Bruhn C, Zemel L, Hofmann K, Stark RW, u. a. Selection of peptides binding to metallic borides by screening M13 phage display libraries. BMC Biotechnology. 2014;14:12.
    6. Nestl B, Hammer S, Nebel B, Hauer B. New Generation of Biocatalysts for Organic Synthesis. Angew Chem Int Ed. 2014;53:3070–95.
    7. Otte K, Kittelberg J, Kirtz M, Nestl B, Hauer B. Whole-Cell One-Pot Biosynthesis of Azelaic Acid. ChemCatChem. 2014;6,4:1003–9.
    8. Subinya M, Steudle A, Nestl B, Nebel B, Hauer B, Stubenrauch C, u. a. Physico-chemical aspects of lipase B from Candida antarctica in bicontinuous microemulstions. Langmuir. 2014;30:2993–3000.
    9. Nestl B, Hauer B. Engineering of Flexible Loops in Enzymes. ACS Catalysis. 2014;4:3201–11.
    10. Nebel B, Scheps D, Honda MS, Nestl B, Breuer M, Wagner H, u. a. Biooxidation of n-butane to 1-butanol by engineered P450 monooxygenase under increased pressure. Journal of Biotechnology. 2014;191:86–92.
  11. 2013

    1. Zhong L, Hauer B, Rosche B. Catalytic biofilms on structured packing for the production of glycolic acid. J Microbiol Biotechnol. 2013;23:195–204.
    2. Rothenstein D, Facey S, Ploss M, Hans P, Melcher M, Srot V, u. a. Mineralisation of gold nanoparticles using tailored M13 phages. Bioinspired, Biomimetic and Nanobiomaterials. 2013;
    3. Hammer S, Syren P, Seitz M, Nestl B, Hauer B. Squalene hopene cyclases: highly promiscuous and evolable catalysts for stereoselective C-C and C-X bond formation. Curr Opin Chem Biol. 2013;17:293–300.
    4. Scheps D, Honda MS, Richter S, Marisch K, Nestl B, Hauer B. Synthesis of omega-hydroxy dodecanoic acid based on an engineered CYP153A fusion construct. Microbial Biotechnol. 2013;6:694–707.
    5. Hammer S, Nestl B, Hauer B. The slumbering synthesis potential in enzymes: how can it be awakened? BIOspektrum. 2013;19:574–6.
    6. Nestl B, Nebel B, Hauer B. Dirigent effects in biocatalysis. Protein Engineering Handbook. 2013;3:1–27.
    7. Nestl B, Hauer B. Protein engineering: chemistry gets the assist. Nat Chem Bio. 2013;9:470–1.
    8. Vallon T, Glemser M, Honda MS, Scheps D, Schmid J, Siemann-Herzberg M, u. a. Production of 1-octanol from n-octane by Pseudomonas putida KT2440. Chemie Ingenieur Technik. 2013;85:841–8.
    9. Kazenwadel C, Klebensberger J, Richter S, Pfannstiel J, Gerken U, Pickel B, u. a. Optimized expression of the dirigent protein AtDIR6 in Pichia pastoris and impact of glycosylation on protein structure and function. Appl Microbiol Biotechnol. 2013;97:7215–27.
    10. Otte K, Kirtz M, Nestl B, Hauer B. Synthesis of 9-oxononanoic acid, a precursor for biopolymers. ChemSusChem. 2013;6:2149–56.
  12. 2012

    1. Reich S, Höffken H, Rosche B, Nestl B, Hauer B. Crystal structure determination and mutagenesis analysis of the ene reductase NCR. ChemBioChem. 2012;13:2400–7.
    2. Seitz M, Klebensberger J, Siebenhaller S, Breuer M, Siedenburg G, Jendrossek D, u. a. Substrate specificity of a novel squalene-hopene cyclase from Zymomonas mobilis. J Mol Catal B: Enzym. 2012;84:72–7.
    3. Mückschel B, Simon O, Klebensberger J, Graf N, Rosche B, Altenbuchner J, u. a. Ethylene Glycol Metabolism of Pseudomonas putida. Appl Environ Microbiol. 2012;78:8531–9.
    4. Honda MS, Scheps D, Kühnel L, Venegas E, Seifert A, Nestl B, u. a. Bacterial CYP153A monooxygenases for the synthesis of omega-hydroxylated fatty acids. Chem Commun. 2012;48:5115–7.
    5. Kazenwadel C, Eiben S, Maurer S, Beuttler H, Wetzl D, Hauer B, u. a. Thiol-functionalization of acrylic ester monomers catalyzed by immobilized Humicola insolens cutinase. Enzyme Microbiol Technol. 2012;51:9–15.
    6. Hammer S, Dominicus J, Syren P, Nestl B, Hauer B. Stereoselective Friedel-Crafts alkylation catalyzed by squalene hopene cyclases. Tetrahedron. 2012;68:7624–9.
  13. 2011

    1. Scheps D, Honda MS, Hoffmann H, Nestl B, Hauer B. Regioselective w-hydroxylation of medium-chain n-alkanes and primary alcohols by CYP153 enzymes from Mycobacterium marinum and Polaromonas sp. strain JS666. Org Biomol Chem. 2011;9:6727–33.
    2. Lalli M, Facey S, Hauer B. Protein Containers—Promising Tools for the Future. ChemBioChem. 2011;12:1519–21.
    3. Seifert A, Antonovici M, Hauer B, Pleiss J. An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1. ChemBioChem. 2011;12:1346–51.
    4. Beuttler H, Hoffmann J, Jeske M, Hauer B, Schmid R, Altenbuchner J, u. a. Biosynthesis of zeaxanthin in recombinant Pseudomonas putida. ApplMicrobiolBiotechnol. 2011;89:11377–11347.
    5. Alissandrotos A, Baudendistel N, Hauer B, Baldenius K, Flitsch S, Halling P. Biocompatible functionalisation of starch. ChemCommun. 2011;47:683–5.
    6. Nestl B, Nebel B, Hauer B. Recent progress in industrial biocatalysis. Curr Opin Chem Biol. 2011;15:187–93.
  14. 2010

    1. Koschorreck K, Kazenwadel C, Schmid R, Hauer B. Heterologous expression, characterization and site-directed mutagenesis of cutinase CUTAB1 from Alternaria brassicicola. Appl Microbiol Biotechnol. 2010;87:991–7.
    2. Güven A, Fioroni M, Hauer B, Schwaneberg U. Molecular understanding of sterically controlled compound release through an engineered channel protein (FhuA). J Nanotechnology. 2010;8:14.
    3. Mueller N, Stueckler C, Hauer B, Baudendistel N, Housden H, Bruce N, u. a. The Substrate Spectra of Pentaerythritol Tetranitrate Reductase, Morphinone Reductase, N-Ethylmaleimide Reductase and Estrogen-Binding Protein in the Asymmetric Bioreduction of Activated Alkenes. Adv Synth Catal. 2010;325:387–94.
    4. Roepcke C, Muench S, Schulze H, Bachmann T, Schmid R, Hauer B. Analysis of phosphothionate pesticides using a chloroperoxidase pretreatment and acetylcholonesterase biosensor detection. JAgricFood Chem. 2010;58:8748–56.
    5. Fisch F, Fleites C, Delenne M, Baudendistel N, Hauer B, Turkenburg J, u. a. A covalent succinylcysteine-like intermediate in the enzyme-catalyzed transformation of maleate ot fumerate by maleate isomerase. J Am Chem Soc. 2010;132:11455–7.
    6. Syren P, Lindgre E, Hoeffken H, Branneby C, Maurer S, Hauer B, u. a. Increased activity of enzymatic transacylation of acrylates through rational design of lipases. J Mol Catal B. 2010;65:3–10.
    7. Alissandrotos A, Baudendistel N, Flitsch S, Hauer B, Halling P. Lipase-catalysed acylation of starch and determination of the degree of substitution by methanolysis and GC. BMC Biotechnology. 2010;10:82.
  15. 2009

    1. Rosche B, Hauer B, Schmid A, Bühler K. Microbial biofilms: a concept for industrial catalysis? Trends Biotechnol. 2009;27(11):636–43.
  16. 2006

    1. Lentz O, Feenstra A, Habicher T, Hauer B, Schmid R, Urlacher V. Altering the regioselectivity of cytochrome P450 CYP102A3 of Bacillus subtilis by using a new versatile assay system. Chembiochem. 2006;7:345–50.
  17. 2003

    1. Doderer K, Schmitt J, Hauer B, Schmid R. High-throughput screening for bacterial epoxide hydrolyase activity. Anal Biochem. 2003;321:131–4.
  18. 2000

    1. Zocher F, Enzelberger M, Bornscheuer U, Hauer B, Wohlleben W, Schmid R. Epoxide hydrolase activity of Streptomyces strains. J Biotechnol. 2000;77:287–92.
  19. 1999

    1. Zocher F, Enzelberger M, Bornscheuer U, Hauer B, Schmid R. A colorimetric assay suitable for screening epoxide hydrolase activity. Anal Chim Acta. 1999;391:345–51.
    2. Hauer B, Schmid R, Enzelberger M, Minning S. Peptides for creation of fusion proteins and their purification by metal ion affinity chromatography. WO. 1999;9960134.
  20. 1998

    1. Enzelberger M, Zocher F, Bornscheuer U, Schmidt-Dannert C, Hauer B, Schmid R. Singularisation of enzyme mutants by use of a cell sorter and the green fluorescent protein. Bioforum. 1998;21:192–4.
Forschungsgruppe
ORCID
Zum Seitenanfang