This image shows Bernhard Hauer

Bernhard Hauer

Prof. Dr.

Head of the Technical Biochemistry Department
Institute of Biochemistry and Technical Biochemistry
Technical Biochemistry


+49 711 685 63193
+49 711 685 63196

Allmandring 31
70569 Stuttgart
Room: 0.303

  1. 2023

    1. Schell, K., Li, H., Lauterbach, L., Taizoumbe, K.A., Dickschat, J.S., Hauer, B.: Alternative Active Site Confinement in Squalene–Hopene Cyclase Enforces Substrate Preorganization for Cyclization. ACS Catal. 13, 5073--5083 (2023).
    2. Aberle, B., Kowalczyk, D., Massini, S., Egler-Kemmerer, A.-N., Gergel, S., Hammer, S.C., Hauer, B.: Methylation of Unactivated Alkenes with Engineered Methyltransferases To Generate Non-natural Terpenoids. Angewandte Chemie. 62, (2023).
    3. Schneider, A., Ruppert, J., Lystbæk, T.B., Bastian, S., Hauer, B.: Expanding the Cation Cage: Squalene-Hopene Cyclase-Mediated Enantioselective Semipinacol Rearrangement. ACS Catal. 13, 1946--1951 (2023).
    4. Schelle, J.T., Lepoittevin, W., Hauer, B.: Enhanced Semi-Preparative Biotransformation of Cumene Dioxygenase: From Analytical Scale to Product Isolation . Chemie Ingenieur Technik. 95, 607–611 (2023).
    5. Schneider, A., Curado, C., Lystbaek, T.B., Osuna, S., Hauer, B.: Harnessing the Structure and Dynamics of the Squalene-Hopene Cyclase for (−)-Ambroxide Production**. Angewandte Chemie International Edition. 62, e202301607 (2023).
  2. 2022

    1. Benítez-Mateos, A.I., Schneider, A., Hegarty, E., Hauer, B., Paradisi, F.: Spheroplasts preparation boosts the catalytic potential of a squalene-hopene cyclase. Nature Communications. 13, 6269-- (2022).
    2. Rapp, L., Marques, S., Nebel, B., Damborsky, J., Hauer, B.: Engineering CYP153A to Oxyfunctionalize its Inhibitor Dodecylamine Using a LC/MS Based Rapid Flow Analysis Screening. ChemCatChem. (2022).
  3. 2021

    1. Henche, S., Nestl, B., Hauer, B.: Enzymatic Friedel-Crafts Alkylation Using Squalene-Hopene Cyclases. ChemCatChem. (2021).
    2. Heinemann, P., Armbruster, D., Hauer, B.: Active-site loop variations adjust activity and selectivity of the cumene dioxygenase. Nature Communications. 12, 1095 (2021).
    3. Wissner, J., Schelle, J., Escobedo, W., Vogel, A., Hauer, B.: Semi‐Rational Engineering of Toluene Dioxygenase from Pseudomonas putida F1 towards Oxyfunctionalization of Bicyclic Aromatics. Advanced Synthesis & Catalysis. 363, 1–11 (2021).
    4. Bengel, L., Aberle, B., Egler-Kemmerer, A.-N., Kienzle, S., Hauer, B., Hammer, S.: Engineered enzymes enable selective N-alkylation of pyrazoles with simple haloalkanes. Angewandte Chemie International Edition. 60, 2–9 (2021).
    5. Schneider, A., Jegl, P., Hauer, B.: Stereoselective Directed Cationic Cascades Enabled by Molecular Anchoring in Terpene Cyclases. Angewandte Chemie International Edition. 60, 2–8 (2021).
    6. Hunold, A., Escobedo, W., Potoudis, E., Resende, D., Farr, T., Syrén, P., Hauer, B.: Assembly of a Rieske non-heme iron oxygenase multicomponent system from Phenylobacterium immobile E DSM 1986 enables pyrazon cis-dihydroxylation in E. coli. Applied Microbiology and Biotechnology. 105, 2003–20015 (2021).
    7. Escobedo, W., Hammer, S., Wissner, J., Hauer, B.: Fast and easy synthesis of the non-commercially available standard isobutyl monophosphate (ammonium salt). MethodsX. 8, 101455 (2021).
    8. Escobedo, W., Wissner, J., Hauer, B.: A real-time 31 P-NMR-based approach for the assessment of glycerol kinase catalyzed monophosphorylations. MethodsX. 8, (2021).
    9. Farr, T., Wissner, J., Hauer, B.: A simple and efficient method for lyophilization of recombinant E. coli JM109 (DE3) whole-cells harboring active Rieske non-heme iron dioxygenases. MethodsX. 8, (2021).
    10. Wissner, J., Escobedo, W., Vogel, A., Hauer, B.: An engineered toluene dioxygenase for a single step biocatalytical production of (-)-(1S,2R)-cis-1,2-dihydro-1,2-naphthalenediol. Journal of Biotechnology. 326, 37–39 (2021).
    11. Rapp, L., Marques, S., Zukic, E., Rowlinson, B., Sharma, M., Grogan, G., Damborsky, J., Hauer, B.: Substrate Anchoring and Flexibility Reduction in Leads to Highly Improved Efficiency toward Octanoic Acid. ACS Catalysis. 11, 3182–3189 (2021).
  4. 2020

    1. Klenk, J., Ertl, J., Rapp, L., Fischer, M.-P., Hauer, B.: Expression and characterization of the benzoic acid hydroxylase CYP199A25 from Arthrobacter sp. Molecular Catalysis. 484, (2020).
    2. Hauer, B.: Embracing Nature’s Catalysts: A Viewpoint on the Future of Biocatalysis. ACS Catalysis. 10, 8418–8427 (2020).
    3. Wissner, J., Ludwig, J., Escobedo, W., Hauer, B.: Strategy for identification of cis -dihydrodiendiol-degrading dehydrogenases in E. coli BW25113. MethodsX. 7, 101143 (2020).
    4. Wissner, J., Ludwig, L., Escobedo, W., Hauer, B.: An enhanced toluene dioxygenase platform for the production of cis-1,2-dihydrocatechol in Escherichia coli BW25113 lacking glycerol dehydrogenase activity. Journal of Biotechnology. (2020).
    5. Heinemann, P., Rapp, L., Hauer, B.: Loops und Tunnel: unterschätzte Elemente in Enzymen. BIOspektrum. 26.4, 434–436 (2020).
    6. Wissner, J., Escobedo, W., Heinemann, P., Hunold, A., Hauer, B.: Methods for the detection and analysis of dioxygenase catalyzed dihydroxylation in mutant derived libraries. Methods in Enzymology. 1–31 (2020).
  5. 2019

    1. Klaus, T., Seifert, A., Häbe, T., Nestl, B., Hauer, B.: An Enzyme Cascade Synthesis of Vanillin. Catalysts. 9, (2019).
    2. Bornscheuer, U., Hauer, B., Jaeger, K., Schwaneberg, U.: Directed Evolution Empowered Redesign of Natural Proteins for the Sustainable Production of Chemicals and Pharmaceuticals. Angewandte Chemie International Edition. 58, 36–40 (2019).
    3. Demming, R., Hammer, S., Nestl, B., Gergel, S., Fademrecht, S., Pleiss, J., Hauer, B.: Asymmetric Enzymatic Hydration of Unactivated, Aliphatic Alkenes. Angew Chem Int Ed Engl. 58, 173–177 (2019).
    4. Hinner, L., Wissner, J., Hauer, B., Nebel, B.: Efficient cellulose dissolution in a tertiary EHEMIM-EMIMOAc-water system. Journal of Molecular Liquids. 281, 236–242 (2019).
    5. Klenk, J., Kontny, L., Escobedo, W., Nebel, B., Hauer, B.: Oxyfunctionalization of nonsteroidal anti‐inflammatory drugs by filamentous‐fungi. Journal of Applied Microbiology. 127, 724–738 (2019).
    6. Allgaier, M., Halder, J., Kittelberger, J., Hauer, B., Nebel, B.: A simple and robust LC-ESI single quadrupole MS-based method to analyze neonicotinoids in honey bee extracts. MethodsX. 6, 2484–2491 (2019).
    7. Li, W., Jayakody, L., Franden, M., Wehrmann, M., Daun, T., Hauer, B., Blank, L., Beckham, G., Klebensberger, J., Wierckx, N.: Laboratory evolution reveals the metabolic and regulatory basis of ethylene glycol metabolism by Pseudomonas putida KT2440. Environmental Microbiology. 21, 3669–3682 (2019).
  6. 2018

    1. Halder, J., Nestl, B., Hauer, B.: Semi-Rational Engineering of the Naphthalene Dioxygenase from Pseudomonas sp. NCIB 9816-4 towards Selective Asymmetric Dihydroxylation. ChemCatChem. 10, 178–182 (2018).
    2. Facey, S., Nebel, B., Kontny, L., Allgaier, M., Hauer, B.: Rapid and complete degradation of diclofenac by native soil microorganisms. Environmental Technology & Innovation. 10, 55–61 (2018).
    3. Kress, N., Halder, J., Rapp, L., Hauer, B.: Unlocked potential of dynamic elements in protein structures: channels and loops. Curr Opin Chem Biol. 47, 109–116 (2018).
    4. Klenk, J., Dubiel, P., Sharma, M., Grogan, G., Hauer, B.: Characterization and structure‐guided engineering of the novel versatile terpene monooxygenase CYP109Q5 from Chondromyces apiculatus DSM436. Microbial Biotechnology. 377–391 (2018).
    5. Demming, R., Fischer, M., Schmid, J., Hauer, B.: (De)hydratases-recent developments and future perspectives. Curr Opin Chem Biol. 43, 43–50 (2018).
    6. Fernandes, A., Halder, J., Nestl, B., Hauer, B., Gernaey, K., Krühne, U.: Biocatalyst Screening with a Twist: Application of Oxygen Sensors Integrated in Microchannels for Screening Whole Cell Biocatalyst Variants. Bioengineering (Basel). 5(2), E30 (2018).
  7. 2017

    1. Klenk, J., Nebel, B., Porter, J., Kulig, J., Hussain, S., Richter, S., Tavanti, M., Turner, N., Hayes, M., Hauer, B.: The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac. Biotechnol J. 12, 1600520 (2017).
    2. Kress, N., Rapp, J., Hauer, B.: Enantioselective Reduction of Citral Isomers in NCR Ene Reductase: Analysis of an Active-Site Mutant Library. ChemBioChem. 18, 717–720 (2017).
    3. Nestl, B., Geinitz, C., Popa, S., Rizek, S., Haselbeck, R., Fischer, M., van, D.S., Culler, S., Grogan, G., Hauer, B.: Structural and functional insights into asymmetric enzymatic dehydration of alkenols. Nat Chem Biol. 13, 275–281 (2017).
    4. Demming, R., Otte, K., Nestl, B., Hauer, B.: Optimized Reaction Conditions Enable the Hydration of Non-natural Substrates by the Oleate Hydratase from Elizabethkingia meningoseptica. ChemCatChem. 9, 758–766 (2017).
    5. Schmid, J., Steiner, L., Fademrecht, S., Pleiss, J., Otte, K., Hauer, B.: Biocatalytic study of novel oleate hydratases. J Mol Catal B: Enzym. 133, S243–S249 (2017).
    6. Kühnel, L., Nestl, B., Hauer, B.: Enzymatic Addition of Alcohols to Terpenes by Squalene Hopene Cyclase Variants. ChemBioChem. 18, 2222–2225 (2017).
    7. Bastian, S., Hammer, S., Kress, N., Nestl, B., Hauer, B.: Enabling New Selectivities in the Cyclization of Citronellal by Squalene Hopene Cyclase Variants. ChemCatChem. 9, 4364–4368 (2017).
    8. Darimont, D., Weissenborn, M., Nebel, B., Hauer, B.: Modulating proposed electron transfer pathways in P450BM3 led to improved activity and coupling efficiency. Bioelectrochemistry. 119, 119–123 (2017).
    9. Otte, K., Maurer, E., Kirtz, M., Grabs, D., Althoff, E., Bartsch, S., Vogel, A., Nestl, B., Hauer, B.: Synthesis of sebacic acid using a de novo designed retro-aldolase as key catalyst. ChemCatChem. 9, 1378–1382 (2017).
  8. 2016

    1. Wetzl, D., Bolsinger, J., Nestl, B., Hauer, B.: α-Hydroxylation of Carboxylic Acids Catalyzed by Taurine Dioxygenase. ChemCatChem. 8, 1361–1366 (2016).
    2. Notonier, S., Gricman, L., Pleiss, J., Hauer, B.: Semi-rational protein engineering of CYP153A BM3 for efficient terminal hydroxylation of short to long chain fatty acids. ChemBioChem. 17, 1550–1557 (2016).
    3. Hoffmann, S., Weissenborn, M., Gricman, L., Notonier, S., Pleiss, J., Hauer, B.: The Impact of Linker Length on P450 Fusion Constructs: Activity, Stability and Coupling. ChemCatChem. 8, 1591–1597 (2016).
    4. Moghimian, P., Kilper, S., Srot, V., Rothenstein, D., Facey, SJ., Hauer, B., Bill, J., van, A.PA.: Phage-assisted assembly of organic–inorganic hybrid bilayers. International Journal of Materials Research. (2016).
    5. Syren, P., Henche, S., Eichler, A., Nestl, B., Hauer, B.: Squalene-hopene cyclases - evolution, dynamics and catalytic scope. Curr. Opin. Struct. Biol. 41, 73–82 (2016).
    6. Fademrecht, S., Scheller, P., Nestl, B., Hauer, B., Pleiss, J.: Identification of imine reductase-specific sequence motifs. Proteins. 84, 600–610 (2016).
    7. Reich, S., Nestl, B., Hauer, B.: Loop Grafted Old Yellow Enzymes in the Bienzymatic Cascade Reduction of Allylic Alcohols. ChemBioChem. 17, 561–565 (2016).
    8. Melcher, M., Facey, S., Henkes, T., Subkowski, T., Hauer, B.: Accelerated nucleation of hydroxyapatite using an engineered hydrophobin fusion protein. Biomacromolecules. (2016).
    9. Löw, S., Löw, I., Weissenborn, M., Hauer, B.: Enhanced Ene-Reductase Activity through Alteration of Artificial Nicotinamide Cofactor Substituents. ChemCatChem. 8, 911–915 (2016).
    10. Hoffmann, S., Danesh-Azari, H.-R., Spandolf, C., Weissenborn, M., Grogan, G., Hauer, B.: Structure-guided redesign of for the improved terminal hydroxylation of fatty acids. ChemCatChem. 8, 3234–3239 (2016).
    11. Hammer, S., Syren, P., Hauer, B.: Substrate Pre-Folding and Water Molecule Organization Matters for Terpene Cyclase Catalyzed Conversion of Unnatural Substrates. Chemistry Select. 1, 3589–3593 (2016).
    12. Llaudet, E., Darimont, D., Samba, R., Matiychyn, I., Stelzle, M., Weissenborn, M., Hauer, B.: Expanding an Efficient, Electrically Driven and CNT-Tagged P450 System into the Third Dimension: A Nanowired CNT-Containing and Enzyme-Stabilising 3 D Sol-Gel Electrode. ChemBioChem. 17, 1367–1373 (2016).
    13. Lenz, M., Scheller, P., Richter, S., Hauer, B., Nestl, B.: Cultivation and purification of two stereoselective imine reductases from Streptosporangium roseum and Paenibacillus elgii. Protein Expr. Purif. (2016).
  9. 2015

    1. Reznicek, O., Facey, SJ., Hauer, B.: Draft Genome Sequence of a Papaverine-Degrading, Gram-positive Arthrobacter sp., Isolated from Soil Near Hohenheim, Germany. Genome Announcements. 3, e00422-15 (2015).
    2. Hammer, S., Marjanovic, A., Dominicus, J., Nestl, B., Hauer, B.: Squalene Hopene Cyclases - Potency as Protonases for Stereoselective Brønsted Acid Catalysis. Nature Chemical Biology. 11, 121–126 (2015).
    3. Steudle, A., Nestl, B., Hauer, B., Stubenrauch, C.: Activity of squalene-hopene cyclases in bicontinuous microemulsions. Colloids and Surfaces B: Biointerfaces. 135, 735–741 (2015).
    4. Lonsdale, T., Lauterbach, L., Honda, M.S., Nestl, B., Hauer, B., Lenz, O.: H2-driven biotransformation of n-octane to Q1 1-octanol by Q2 a recombinant Pseudomonas putida strain co-synthesizing an O2-tolerant hydrogenase and a P450 monooxygenase. Chem. Commun. 51, 16173–16175 (2015).
    5. Scheller, P., Lenz, M., Hammer, S., Hauer, B., Nestl, B.: Imine Reductase-Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones. ChemCatChem. 7, 3239–3242 (2015).
    6. Sandig, B., Michalek, L., Vlahovic, S., Antonovici, M., Hauer, B., Buchmeiser, M.: A Monolithic Hybrid Cellulose-2.5-Acetate/Polymer Bioreactor for Biocatalysis under Continuous Liquid-Liquid Conditions Using a Supported Ionic Liquid Phase. Chemistry. 21, 15835–15842 (2015).
    7. Reznicek, O., Luesken, F., Facey, SJ., Hauer, B.: Draft Genome Sequence of Phenylobacterium immobile Strain E (DSM 1986), Isolated from Uncontaminated Soil in Ecuador. Genome Announcements. 3, e00420-15 (2015).
    8. Lundemo, M., Notonier, S., Striedner, G., Hauer, B., Woodley, J.: Process limitations of a whole-cell P450 catalyzed reaction using a CYP153A-CPR fusion construct expressed in Escherichia coli. Appl. Microbiol. Biotechnol. 100, 1197–1208 (2015).
    9. Gally, C., Nestl, B., Hauer, B.: Engineering Rieske Non-Heme Iron Oxygenases for the Asymmetric Dihydroxylation of Alkenes. Angew. Chem. Int. Ed. 54, 12952–12956 (2015).
    10. Löw, S., Nestl, B., Weissenborn, M., Zepeck, F., Hauer, B.: Process Investigations on the One-Pot Synthesis of Rifamycin S Avoiding Chlorinated Solvents. Org. Process Res. Dev. 19, 1544–1547 (2015).
    11. Reznicek, O., Facey, SJ., de, W.PP., Teunissen, AWRH., de, B.JAM., Nijland, JG., Driessen, AJM., Hauer, B.: Improved xylose uptake in Saccharomyces cerevisiae due to directed evolution of galactose permease Gal2 for sugar co-consumption. Journal of Applied Microbiology. 119, 99–111 (2015).
    12. Otte, K., Hauer, B.: Enzyme engineering in the context of novel pathways and products. Curr Opin Biotechnol. 35, 16–22 (2015).
  10. 2014

    1. Reich, S., Kress, N., Nestl, B., Hauer, B.: Variations in the stability of NCR ene reductase by rational enzyme loop modulation. J. Struct. Biol. 185, 228–233 (2014).
    2. Moghimian, P., Srot, V., Rothenstein, D., Facey, SJ., Harnau, L., Hauer, B., Bill, J., van, A.PA.: Adsorption and Self-Assembly of M13 Phage into Directionally Organized Structures on C and SiO2 Films. Langmuir. 30, 11428–11432 (2014).
    3. Scheller, P., Fademrecht, S., Hofelzer, S., Pleiss, J., Leipold, F., Turner, N., Nestl, B., Hauer, B.: Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases. ChemBioChem. 15, 2201–2204 (2014).
    4. Syren, P., Hammer, S., Classen, B., Hauer, B.: Entropy is Key to the Formation of Pentacyclic Terpenoids by Enzyme-Catalyzed Polycyclization. Angew. Chem. Int. Ed. 53, 4845–4849 (2014).
    5. Ploss, M., Facey, SJ., Bruhn, C., Zemel, L., Hofmann, K., Stark, RW., Albert, B., Hauer, B.: Selection of peptides binding to metallic borides by screening M13 phage display libraries. BMC Biotechnology. 14, 12 (2014).
    6. Nestl, B., Hauer, B.: Engineering of Flexible Loops in Enzymes. ACS Catalysis. 4, 3201–3211 (2014).
    7. Nestl, B., Hammer, S., Nebel, B., Hauer, B.: New Generation of Biocatalysts for Organic Synthesis. Angew. Chem. Int. Ed. 53, 3070–3095 (2014).
    8. Otte, K., Kittelberg, J., Kirtz, M., Nestl, B., Hauer, B.: Whole-Cell One-Pot Biosynthesis of Azelaic Acid. ChemCatChem. 6,4, 1003–1009 (2014).
    9. Subinya, M., Steudle, A., Nestl, B., Nebel, B., Hauer, B., Stubenrauch, C., Engelskirchen, S.: Physico-chemical aspects of lipase B from Candida antarctica in bicontinuous microemulstions. Langmuir. 30, 2993–3000 (2014).
    10. Nebel, B., Scheps, D., Honda, M.S., Nestl, B., Breuer, M., Wagner, H., Breitscheidel, B., Kratz, D., Hauer, B.: Biooxidation of n-butane to 1-butanol by engineered P450 monooxygenase under increased pressure. Journal of Biotechnology. 191, 86–92 (2014).
  11. 2013

    1. Zhong, L., Hauer, B., Rosche, B.: Catalytic biofilms on structured packing for the production of glycolic acid. J. Microbiol. Biotechnol. 23, 195–204 (2013).
    2. Scheps, D., Honda, M.S., Richter, S., Marisch, K., Nestl, B., Hauer, B.: Synthesis of omega-hydroxy dodecanoic acid based on an engineered CYP153A fusion construct. Microbial. Biotechnol. 6, 694–707 (2013).
    3. Hammer, S., Nestl, B., Hauer, B.: The slumbering synthesis potential in enzymes: how can it be awakened? BIOspektrum. 19, 574–576 (2013).
    4. Rothenstein, D., Facey, S., Ploss, M., Hans, P., Melcher, M., Srot, V., von, A.P., Hauer, B., Bill, J.: Mineralisation of gold nanoparticles using tailored M13 phages. Bioinspired, Biomimetic and Nanobiomaterials. (2013).
    5. Hammer, S., Syren, P., Seitz, M., Nestl, B., Hauer, B.: Squalene hopene cyclases: highly promiscuous and evolable catalysts for stereoselective C-C and C-X bond formation. Curr. Opin. Chem. Biol. 17, 293–300 (2013).
    6. Nestl, B., Nebel, B., Hauer, B.: Dirigent effects in biocatalysis. Protein Engineering Handbook. 3, 1–27 (2013).
    7. Nestl, B., Hauer, B.: Protein engineering: chemistry gets the assist. Nat. Chem. Bio. 9, 470–471 (2013).
    8. Vallon, T., Glemser, M., Honda, M.S., Scheps, D., Schmid, J., Siemann-Herzberg, M., Hauer, B., Takors, R.: Production of 1-octanol from n-octane by Pseudomonas putida KT2440. Chemie Ingenieur Technik. 85, 841–848 (2013).
    9. Kazenwadel, C., Klebensberger, J., Richter, S., Pfannstiel, J., Gerken, U., Pickel, B., Schaller, A., Hauer, B.: Optimized expression of the dirigent protein AtDIR6 in Pichia pastoris and impact of glycosylation on protein structure and function. Appl Microbiol Biotechnol. 97, 7215–7227 (2013).
    10. Otte, K., Kirtz, M., Nestl, B., Hauer, B.: Synthesis of 9-oxononanoic acid, a precursor for biopolymers. ChemSusChem. 6, 2149–2156 (2013).
  12. 2012

    1. Reich, S., Höffken, H., Rosche, B., Nestl, B., Hauer, B.: Crystal structure determination and mutagenesis analysis of the ene reductase NCR. ChemBioChem. 13, 2400–2407 (2012).
    2. Seitz, M., Klebensberger, J., Siebenhaller, S., Breuer, M., Siedenburg, G., Jendrossek, D., Hauer, B.: Substrate specificity of a novel squalene-hopene cyclase from Zymomonas mobilis. J Mol Catal B: Enzym. 84, 72–77 (2012).
    3. Mückschel, B., Simon, O., Klebensberger, J., Graf, N., Rosche, B., Altenbuchner, J., Huber, A., Hauer, B.: Ethylene Glycol Metabolism of Pseudomonas putida. Appl Environ Microbiol. 78, 8531–8539 (2012).
    4. Honda, M.S., Scheps, D., Kühnel, L., Venegas, E., Seifert, A., Nestl, B., Hauer, B.: Bacterial CYP153A monooxygenases for the synthesis of omega-hydroxylated fatty acids. Chem. Commun. 48, 5115–5117 (2012).
    5. Kazenwadel, C., Eiben, S., Maurer, S., Beuttler, H., Wetzl, D., Hauer, B., Koschorreck, K.: Thiol-functionalization of acrylic ester monomers catalyzed by immobilized Humicola insolens cutinase. Enzyme Microbiol. Technol. 51, 9–15 (2012).
    6. Hammer, S., Dominicus, J., Syren, P., Nestl, B., Hauer, B.: Stereoselective Friedel-Crafts alkylation catalyzed by squalene hopene cyclases. Tetrahedron. 68, 7624–7629 (2012).
  13. 2011

    1. Lalli, M., Facey, S., Hauer, B.: Protein Containers—Promising Tools for the Future. ChemBioChem. 12, 1519–1521 (2011).
    2. Scheps, D., Honda, M.S., Hoffmann, H., Nestl, B., Hauer, B.: Regioselective w-hydroxylation of medium-chain n-alkanes and primary alcohols by CYP153 enzymes from Mycobacterium marinum and Polaromonas sp. strain JS666. Org. Biomol. Chem. 9, 6727–6733 (2011).
    3. Seifert, A., Antonovici, M., Hauer, B., Pleiss, J.: An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1. ChemBioChem. 12, 1346–1351 (2011).
    4. Beuttler, H., Hoffmann, J., Jeske, M., Hauer, B., Schmid, R., Altenbuchner, J., Urlacher, V.: Biosynthesis of zeaxanthin in recombinant Pseudomonas putida. Appl.Microbiol.Biotechnol. 89, 11377–11347 (2011).
    5. Alissandrotos, A., Baudendistel, N., Hauer, B., Baldenius, K., Flitsch, S., Halling, P.: Biocompatible functionalisation of starch. Chem.Commun. 47, 683–685 (2011).
    6. Nestl, B., Nebel, B., Hauer, B.: Recent progress in industrial biocatalysis. Curr. Opin. Chem. Biol. 15, 187–193 (2011).
  14. 2010

    1. Koschorreck, K., Kazenwadel, C., Schmid, R., Hauer, B.: Heterologous expression, characterization and site-directed mutagenesis of cutinase CUTAB1 from Alternaria brassicicola. Appl. Microbiol. Biotechnol. 87, 991–997 (2010).
    2. Güven, A., Fioroni, M., Hauer, B., Schwaneberg, U.: Molecular understanding of sterically controlled compound release through an engineered channel protein (FhuA). J. Nanotechnology. 8, 14 (2010).
    3. Mueller, N., Stueckler, C., Hauer, B., Baudendistel, N., Housden, H., Bruce, N., Faber, K.: The Substrate Spectra of Pentaerythritol Tetranitrate Reductase, Morphinone Reductase, N-Ethylmaleimide Reductase and Estrogen-Binding Protein in the Asymmetric Bioreduction of Activated Alkenes. Adv. Synth. Catal. 325, 387–394 (2010).
    4. Roepcke, C., Muench, S., Schulze, H., Bachmann, T., Schmid, R., Hauer, B.: Analysis of phosphothionate pesticides using a chloroperoxidase pretreatment and acetylcholonesterase biosensor detection. J.Agric.Food Chem. 58, 8748–8756 (2010).
    5. Fisch, F., Fleites, C., Delenne, M., Baudendistel, N., Hauer, B., Turkenburg, J., Hart, S., Bruce, N., Grogan, G.: A covalent succinylcysteine-like intermediate in the enzyme-catalyzed transformation of maleate ot fumerate by maleate isomerase. J. Am. Chem. Soc. 132, 11455–11457 (2010).
    6. Syren, P., Lindgre, E., Hoeffken, H., Branneby, C., Maurer, S., Hauer, B., Hult, K.: Increased activity of enzymatic transacylation of acrylates through rational design of lipases. J Mol. Catal. B. 65, 3–10 (2010).
    7. Alissandrotos, A., Baudendistel, N., Flitsch, S., Hauer, B., Halling, P.: Lipase-catalysed acylation of starch and determination of the degree of substitution by methanolysis and GC. BMC Biotechnology. 10, 82 (2010).
  15. 2009

    1. Rosche, B., Hauer, B., Schmid, A., Bühler, K.: Microbial biofilms: a concept for industrial catalysis? Trends Biotechnol. 27(11), 636–43 (2009).
  16. 2006

    1. Lentz, O., Feenstra, A., Habicher, T., Hauer, B., Schmid, R., Urlacher, V.: Altering the regioselectivity of cytochrome P450 CYP102A3 of Bacillus subtilis by using a new versatile assay system. Chembiochem. 7, 345–350 (2006).
  17. 2003

    1. Doderer, K., Schmitt, J., Hauer, B., Schmid, R.: High-throughput screening for bacterial epoxide hydrolyase activity. Anal Biochem. 321, 131–134 (2003).
  18. 2000

    1. Zocher, F., Enzelberger, M., Bornscheuer, U., Hauer, B., Wohlleben, W., Schmid, R.: Epoxide hydrolase activity of Streptomyces strains. J Biotechnol. 77, 287–292 (2000).
  19. 1999

    1. Zocher, F., Enzelberger, M., Bornscheuer, U., Hauer, B., Schmid, R.: A colorimetric assay suitable for screening epoxide hydrolase activity. Anal Chim Acta. 391, 345–351 (1999).
    2. Hauer, B., Schmid, R., Enzelberger, M., Minning, S.: Peptides for creation of fusion proteins and their purification by metal ion affinity chromatography. WO. 9960134, (1999).
  20. 1998

    1. Enzelberger, M., Zocher, F., Bornscheuer, U., Schmidt-Dannert, C., Hauer, B., Schmid, R.: Singularisation of enzyme mutants by use of a cell sorter and the green fluorescent protein. Bioforum. 21, 192–194 (1998).
To the top of the page