Dr.

Philipp Rathert

group leader
Institute of Biochemistry

Contact

0711 685 64388
0711 685 64392

Allmandring 31
70569 Stuttgart
Germany
Room: 01.177

Subject

A central question of epigenome research is how chromatin or DNA binding proteins interact with one another to switch genes on or off at the right time point to establish and maintain a healthy cellular state. Our group investigates the dynamics and wiring of chromatin regulators, as well as the induced transcriptional output under different conditions using state-of-the-art functional genetic tools (RNAi or CRISPR/Cas9) with cell biology methods and biochemical assays.

Selected Publications

  • Rathert P & Roth M, Neumann T, et al. Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature. 2015;525(7570):543-547.
  • Dhayalan A, Rajavelu A, Rathert P, et al. The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. J Biol Chem. 2010;285(34):26114-26120.
  • Rathert P, Dhayalan A, Murakami M, et al. Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol. 2008;4(6):344-346.
  • Rathert P, Zhang X, Freund C, Cheng X, Jeltsch A. Analysis of the Substrate Specificity of the Dim-5 Histone Lysine Methyltransferase Using Peptide Arrays. Chem Biol. 2008;15(1):5-11.

Link to the Google-Scholar publication list

2012 - 2015                      Institute of Molecular Pathology, Vienna, Austria
2010 - 2012                      Scientist, Cellzome, Heidelberg, Germany
2008 - 2010                      Scientist, Active Motif, Brussels, Belgium
2007 - 2008                      PostDoc, Jacobs University Bremen, Germany
2004 - 2007                      PhD, Biochemistry, Jacobs University Bremen, Germany
1998 - 2004                      Study of Biology, University of Marburg, Germany

 

Stipends

2013 - 2015                      Marie Curie Fellow
2008 - 2010                      Marie Curie Fellow