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A central question of epigenome research is how chromatin or DNA binding proteins interact with one another to switch genes on or off at the right time point to establish and maintain a healthy cellular state. Our group investigates the dynamics and wiring of chromatin regulators, as well as the induced transcriptional output under different conditions using state-of-the-art functional genetic tools (RNAi or CRISPR/Cas9) with cell biology methods and biochemical assays.
- Rathert P & Roth M, Neumann T, et al. Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature. 2015;525(7570):543-547.
- Dhayalan A, Rajavelu A, Rathert P, et al. The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. J Biol Chem. 2010;285(34):26114-26120.
- Rathert P, Dhayalan A, Murakami M, et al. Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol. 2008;4(6):344-346.
- Rathert P, Zhang X, Freund C, Cheng X, Jeltsch A. Analysis of the Substrate Specificity of the Dim-5 Histone Lysine Methyltransferase Using Peptide Arrays. Chem Biol. 2008;15(1):5-11.
Institute of Molecular Pathology, Vienna, Austria
2010 - 2012 Scientist, Cellzome, Heidelberg, Germany
2008 - 2010 Scientist, Active Motif, Brussels, Belgium
2007 - 2008 PostDoc, Jacobs University Bremen, Germany
2004 - 2007 PhD, Biochemistry, Jacobs University Bremen, Germany
1998 - 2004 Study of Biology, University of Marburg, Germany
2013 - 2015
Marie Curie Fellow
2008 - 2010 Marie Curie Fellow