Bernhard Hauer is the head of the department and involved in various projects. His research emphases on exploiting the synthetic potential of enzymes. Particular effort is being made on the engineering of active site loops and channels to control substrate as well as product selectivities and even to access non-physiological chemistry.
Jürgen Pleiss - Bioinformatics
How does the sequence and structure of enzymes determine their biochemical function? How to design variants with increased stability, activity, selectivity, or an extended substrate profile? And how to find novel biocatalysts we desired catalytic activity? In tight collaboration with experimental groups, we combine two complementary computational approaches: we analyze the rapidly increasing sequence space of enzymes by data mining, and we explore complex enzyme-substrate-solvent systems by molecular dynamics simulations.
The Nestl research groups aims to expand the biocatalyst toolbox for the synthesis of chiral amines and N-heterocycles. The interest of the research group ranges from the exploitation and engineering of new enzymes catalysts to the application of these in synthetic cascade reactions.
The Hammer research group aims to discover, develop and understand new catalytic principles in enzyme-catalyzed reactions. We use rational design and directed evolution to generate new enzyme function for previously unknown C-C and C-X bond forming reactions.