New publication in "Genes"

New publication in "Genes"

DNA methylation is critically involved in the regulation of chromatin states and cell-type specific gene expression. The exclusive expression of imprinted genes from either the maternal or the paternal allele is regulated by allele-specific DNA methylation at imprinting control regions. In this publication in “Genes”, we performed epigenome editing to induce targeted DNA demethylation at such region and observed stable demethylation and reprogramming of the locus. Our data illustrate the ability of epigenome editing to implement long-term changes of the DNA methylation at imprinting control regions after a single transient treatment, potentially paving the way for therapeutic epigenome editing approaches in the treatment of imprinting disorders.