During the last years, several publications have reported variable levels of N6-methyldeoxyadenosine (m6dA) in human genomic DNA and connected it with effects on cell physiology and in human diseases. However, other publications raised doubts on these findings including the existence and levels of m6dA in human cells, its way of incorporation, potential biological effects, and the validity of proposed human N6-methyltransferases (MTases). This project aims to pursue new research approaches to investigate the occurrence and biological function of m6dA in human DNA.
Contact
Albert Jeltsch
Prof. Dr.Head of Biochemistry department and acting director IBTB