New research project

Lysine methylation is a widespread post-translational protein modification introduced by protein lysine methyltransferases. Lysine methylation regulates many biological processes, including protein stability, signaling pathways, immune response, gene expression, and cell cycle. In addition, it is known that proteins of intracellular pathogens can be modified by host cell enzymes. This new research project supported by the DFG investigates the lysine methylation of SARS-CoV-2 proteins by human protein lysine methyltransferases and its biological impact.