November 22, 2020 /

New publication in "IJMS"

Regulation of the activity of a protein methyltransferase by automethylation

New publication in "International Journal of Molecular Science"

The methylation of proteins is an important protein modification with a variety of functions. Protein methylation is incorporated by protein methyltransferases, the activity of which must be very well regulated. In this work we investigate a protein methyl transferase from yeast and show that its activity is controlled via automethylation. As a result, this enzyme could serve as a cellular sensor for the concentration of the essential methyl group donor S-adenosyl-L-methionine. Furthermore, our work shows that it is possible to control the activity of protein methyltransferases by rationally designing automethylation.
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