Y3H system to identify reader-proteins

New publication in "Epigenetics & Chromatin"

January 28, 2018 /

Y3H system for reader-protein screening

New publication in "Epigenetics & Chromatin"

Chemical modifications of histone proteins are important epigenetic marks with have essential roles in chromatin regulation. The biological effects of these modifications are meditated by so called “reader” proteins, which specifically bind to them and recruit other effectors to the site of modification. This study introduces a modified yeast-three-hybrid system (Y3H) to screen for novel methyl-lysine readers. It will help to identify novel players in chromatin regulation and better understand the pathways in epigenetic information processing.


Link to the manuscript

Contact Prof. Dr. Albert Jeltsch
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