March 1, 2020

The BMBF project HyTech has been granted to our group, in which course we will deal with the engineering of Hydratases (EC4.2.1.x). These enzymes catalyze the addition of a water-molecule to non-activated carbon-carbon double bonds and thereby produce primary, secondary or tertiary alcohols with excellent atom economy, high regio- and stereoselectivity, respectively. This asymmetric hydration is currently impossible in organic chemistry even though the products are of high industrial interest. Together with recent enzyme engineering tools hydratases emerge as a powerful tool for generating various value-added products. Our group will focus on enzymes catalyzing diverse hydration reactions to open up their product space towards flavor and fragrance ingredients, pharmacological intermediates and pheromone building blocks.

To the top of the page