This image shows Sara Weirich

Sara Weirich


Group leader
Abteilung Biochemie, Institut für Biochemie und Technische Biochemie


+49 711 685 64387
+49 711 685 64392

Allmandring 31
70569 Stuttgart
Room: 01.183


Protein methyltransferase, Protein methylation, Somatic tumor mutations, Artificial epigenetic Circuits, MALDI mass spectroscopy, SPOT peptide synthesis

Publikation list of Sara Weirich at Google Scholar


Selected publikations

Schuhmacher MK, Beldar S, Khella MS, Bröhm A, Ludwig J, Tempel W, Weirich S, Min J, Jeltsch A. Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate. Communications Biology 3, 511 (2020).

Dong C, Chen SJ, Melnykov A, Weirich S, Sun K, Jeltsch A, Varshavsky A, Min J. Recognition of nonproline N-terminal residues by the Pro/N-degron pathway. Proc Natl Acad Sci USA 117, 14158-14167 (2020).

Weirich S, Schuhmacher MK, Kudithipudi S, Lungu C, Ferguson AD, Jeltsch A. Analysis of the Substrate Specificity of the SMYD2 Protein Lysine Methyltransferase and Discovery of Novel Non-Histone Substrates. Chembiochem. 2020 Jan 15;21(1-2):256-264.

Ullrich T, Weirich S, Jeltsch A. Development of an epigenetic tetracycline sensor system based on DNA methylation. PLoS One 15, e0232701 (2020).

Bröhm A, Elsawy H, Rathert P, Kudithipudi S, Schoch T, Schuhmacher MK, Weirich S, Jeltsch A. Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate Its Catalytic Activity. J Mol Biol. 2019 Aug 9;431(17):3068-3080.

Schuhmacher MK, Rolando M, Bröhm A, Weirich S, Kudithipudi S, Buchrieser C, Jeltsch A. The Legionella pneumophila Methyltransferase RomA Methylates Also Non-histone Proteins during Infection. J Mol Biol. 2018 Jun 22;430(13):1912-1925.

Jurkowska RZ, Qin S, Kungulovski G, Tempel W, Liu Y, Bashtrykov P, Stiefelmaier J, Jurkowski TP, Kudithipudi S, Weirich S, Tamas R, Wu H, Dombrovski L, Loppnau P, Reinhardt R, Min J, Jeltsch A. H3K14ac is linked to methylation of  H3K9 by the triple Tudor domain of SETDB1. Nat Commun. 2017 Dec 12;8(1):2057.

Weirich S, Kudithipudi S, Jeltsch A. Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex. Mol Oncol. 2017 Apr;11(4):373-387.

Weirich S, Kudithipudi S, Jeltsch A. Specificity of the SUV4-20H1 and SUV4-20H2 protein lysine methyltransferases and methylation of novel substrates. J Mol Biol. 2016 Jun 5;428(11):2344-2358.

Weirich S, Kusevic D, Kudithipudi S, Jeltsch A. Investigation of the methylation of Numb by the SET8 protein lysine methyltransferase. Sci Rep. 2015 Sep 22;5:13813.

Weirich S, Kudithipudi S, Kycia I, Jeltsch A. Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme. Clin Epigenetics. 2015 Mar 28;7:36.

Schuhmacher MK, Kudithipudi S, Kusevic D, Weirich S, Jeltsch A. Activity and specificity of the human SUV39H2 protein lysine methyltransferase. Biochim Biophys Acta. 2015 Jan;1849(1):55-63.

Gessmann D, Mager F, Naveed H, Arnold T, Weirich S, Linke D, Liang J, Nussberger S. Improving the resistance of a eukaryotic β-barrel protein to thermal and chemical perturbations. J Mol Biol. 2011 Oct 14;413(1):150-61.


- Laboratory exercise "Biochemical methods for advanced users"

- Supervision of research internships, B.Sc. and M.Sc. theses, and doctoral students

  • 2017-present: Group leader for the work on protein methyltransferases, Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart
  • 2017: Dr. rer. nat., summa cum laude
  • 2012-2017: Doctoral studies at the Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart
  • 2011-2012: Diploma  thesis at Department of Biophysics, Biological Institute, University of Stuttgart
  • 2005-2012: Study of Technical Biology, University of Stuttgart
To the top of the page