Proteins macromolecular structure offers very defined cavities for catalysis. Beyond the primary catalytic sites, enzymes make a multitude of secondary interactions with their substrates. This delivers unique catalyst-control that is often unattainable by classical methods.
We aim to make use of secondary interactions in proteins to develop new catalytic reactions that are beyond the reach of classical catalysts.
Our target is to access previously unknown reactions by discovering new catalytic principles in enzymes. We combine methods from organic chemistry, protein biochemistry and directed evolution to identify, evolve, apply and understand new enzyme function for chemical synthesis.
Publications (selected highlights)
Education and Career
1997-2001 : Chemical Laboratory Assistant (Training, BASF SE)
2001-2005 : Chemical Laboratory Assistant (BASF SE)
2001-2005 : State-certified Technician for Chemistry (BASF SE)
2005-2010 : Studies of Chemistry (Philipps University of Marburg, DE)
2008-2009 : Studies of Chemistry (University of Cambridge, UK)
11.06.2010 : Diplom in Chemistry (Philipps University of Marburg, DE)
2010-2014 : Dissertation with Prof. Bernhard Hauer (University of Stuttgart, DE)
2015-2017 : Postdoctoral position with Prof. Frances Arnold (Caltech, US)
Since 2017 : Research Group Leader (University of Stuttgart, DE)
2011-2014 : Kekulé Fellowship (FCI, Chemical Industry Fund)
2016-2017 : Research Fellowship (DFG, Deutsche Forschungsgemeinschaft)
Since 2019 : Emmy Noether Programme (DFG, Deutsche Forschungsgemeinschaft)