Special issue on Epigenome Editing in "IJMS"

In the last decade, epigenome editing, the locus-specific rewriting of epigenetic information, has been identified as an emerging key technology in basic research in molecular biology and molecular genetics. It has great promise in the field of molecular medicine, where it could help to up- or downregulate disease-associated genes in a durable manner, providing one step towards the aim of causative therapy. Epigenome editing can be achieved by the expression of artificial fusion proteins in the target cell comprinsing one part guiding the proteins to genomic target loci and another part rewriting chromatin marks at the target site. In this Special Issue of the  International Journal of Molecular Sciences, the concepts and applications of epigenome editing are presented at the intersection of molecular epigenetics, biochemistry, and synthetic biology.