New publication in "Life"

July 23, 2021 /

Structure and function of the SUV39H protein lysine methyltransferases

New publication in "Life"

SUV39H1 and SUV39H2 were the first protein lysine methyltransferases that were identified more than 20 years ago. Both enzymes introduce di- and trimethylation at histone H3 lysine 9 (H3K9) and have important roles in the maintenance of heterochromatin and gene repression, but they are also active in the methlyation of non-histone proteins. In this review in LIFE, we summarize our knowledge regarding structure, function and mechanism of both enzymes, and describe their physiological functions as well roles in diseases processes.

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