DNA methylation is essential for human development and health. The Uhrf1 protein was known for targeting of the Dnmt1 DNA methyltransferase to hemimethylated DNA after DNA replication. We show in a new publication in J. Biol. Chem. that Uhrf1 also stimulates the activity and specificity of Dnmt1 in an allosteric mechanism. Our data show that Uhrf1 has multiple roles in support of DNA methylation which explains the essential role of the Uhrf1 protein for DNA methylation.