We report in a new publication in Epigenetics & Chromatin that the PHD domain from TAF3 could be used as affinity reagent for H3K4me3 and replace antibodies in ChIP applications. As described in our previous work and in this manuscript, the application of reading domains has important advantages over the antibody technology. Here, we describe the first H3K4me3 specific reading domain with validated applicative properties. The availability of a new domain for reading an important histone modification will promote the use of recombinant reading domains in place of antibodies.